A fission yeast gene (prr1(+)) that encodes a response regulator implicated in oxidative stress response.
A fission yeast gene (prr1(+)) that encodes a response regulator implicated in oxidative stress response.
复制标题
裂殖酵母基因 (prr1( ))，编码参与氧化应激反应的反应调节因子。
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
Takeshi Mizuno
中科院分区：
文献类型：
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作者：
R. Ohmiya;Chinatsu Kato;Hisami Yamada;H. Aiba;Takeshi Mizuno
对裂殖酵母基因组数据库的检查发现，这种真核微生物拥有一个可能编码一种细菌型组氨酸到天冬氨酸(His-Asp)磷酸传递成分的基因，即反应调节因子。预测的基因命名为prr1(+)(S.pombe Response Reguler)，编码的蛋白质包含一个典型的磷接受受体结构域，前面是哺乳动物热休克因子(HSF)样的DNA结合域。Prr1(+)基因的失活导致突变细胞在应激反应的某些方面出现缺陷，包括对氧化应激、低温和重金属毒性的敏感性。也有研究表明，Prr1是某些基因(如trr1(+)，ctt1(+))转录所必需的，这些基因是由氧化应激诱导的。这些结果表明，His-Asp磷酸传递系统可能参与了一条胁迫激活的信号通路。
An inspection of the Schizosaccharomyces pombe genome database revealed that this eukaryotic microorganism possesses a gene that may encode a bacterial type of histidine-to-aspartate (His-Asp) phosphorelay component, namely, a response regulator. The predicted gene, named prr1(+) (S. pombe response regulator), encodes a protein that contains a typical phospho-accepting receiver domain, preceded by a mammalian heat shock factor (HSF)-like DNA-binding domain. Inactivation of this prr1(+) gene resulted in mutant cells defective in some aspects of stress responses, including sensitivity to oxidative stress, cold-temperature, and heavy metal toxicity. It was also demonstrated that Prr1 is required for the transcription of some genes (e.g., trr1(+), ctt1(+)), which are induced by oxidative stress. These results suggest that a His-Asp phosphorelay system may be involved in a stress-activated signaling pathway in S. pombe.