Preservation of spatial learning in fyn tyrosine kinase knockout mice
Preservation of spatial learning in fyn tyrosine kinase knockout mice
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DOI：
10.1097/00001756-199607080-00032
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发表时间：
1996-07-08
期刊：
影响因子：
1.7
通讯作者：
Prusky, GT
中科院分区：
文献类型：
--
作者：
Huerta, PT;Scearce, KA;Prusky, GT
先前的工作已经表明，敲除小鼠缺乏th fyn酪氨酸激酶基因（fyn-/-）在空间学习受损。在这里，我们重新研究了fyn-/-突变体的空间学习在一个开放的领域水迷宫。与野生型小鼠不同，fyn-/-基因敲除小鼠在置于火山口时通常漂浮不动，但当它们的后脚受到机械刺激时可以充分游泳。在这些条件下，fyn-/-小鼠在定位隐藏平台方面表现出显着的改善。在一次转移试验中，在训练结束时，他们花了不成比例的时间在先前隐藏平台的位置游泳。这些发现表明，fyn-/-基因敲除者能够进行空间学习，但会受到损害，影响他们正常游泳的能力。
PREVIOUS work has shown that knockout mice lacking th fyn tyrosine kinase gene (fyn-/-) are impaired in spatial learning. Here, we have re-examined the spatial learning of fyn-/- mutants in an open field water maze. Unlike wild-type mice, fyn-/- knockouts often floated without moving when placed in the crater but could swim adequately when their hind feet were mechanically stimulated. Under these conditions, fyn-/- mice showed significant improvement over trials in locating a hidden platform. On a transfer trial, at the end of training, they spent a disproportionate amount of time swimming in the location of the previously hidden platform. These findings suggest that fyn-/- knockouts are capable of spatial learning, but suffer an impairment that compromises their ability to swim normally.