Regulation of desmosome assembly and adhesion.
Regulation of desmosome assembly and adhesion.
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DOI：
10.1016/j.semcdb.2004.09.005
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发表时间：
2004-12
影响因子：
7.3
通讯作者：
T. Yin;K. Green
中科院分区：
文献类型：
--
作者：
T. Yin;K. Green
桥粒是高度组织化的细胞间连接，其通过将中间丝锚定到强粘附位点来为组织提供机械完整性。桥粒钙粘蛋白的转录调控指定其表达模式和组装成不同组成的接头，从而定制桥粒在不同细胞和复杂组织内的粘附和形态发生中的功能。桥粒的组装和解体在翻译后受到钙、激酶/磷酸酶活性、蛋白水解加工以及与粘附连接的串扰的调节。翻译后事件还控制斑珠蛋白和斑嗜蛋白的非连接形式的水平。这些犰狳蛋白参与各种核功能，在某些情况下转导调节细胞生长和分化的信号。
Desmosomes are highly organized intercellular junctions that provide mechanical integrity to tissues by anchoring intermediate filaments to sites of strong adhesion. Transcriptional regulation of desmosomal cadherins specifies their expression pattern and assembly into junctions of distinct composition, thus tailoring desmosome functions in adhesion and morphogenesis within different cells and complex tissues. Desmosome assembly and disassembly are regulated post-translationally by calcium, kinase/phosphatase activity, proteolytic processing, and cross talk with adherens junctions. Post-translational events also govern the level of non-junctional forms of plakoglobin and plakophilins. These armadillo proteins participate in various nuclear functions, in some cases transducing signals regulating cell growth and differentiation.