EPIDEMIOLOGIC-STUDY OF WHEEZE, DOCTOR DIAGNOSED ASTHMA, AND COUGH IN PRESCHOOL-CHILDREN IN LEICESTERSHIRE
EPIDEMIOLOGIC-STUDY OF WHEEZE, DOCTOR DIAGNOSED ASTHMA, AND COUGH IN PRESCHOOL-CHILDREN IN LEICESTERSHIRE
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DOI：
10.1136/bmj.306.6889.1386
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发表时间：
1993-05-22
影响因子：
105.7
通讯作者：
SIMPSON, H
中科院分区：
文献类型：
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作者：
LUYT, DK;BURTON, PR;SIMPSON, H
目的：了解5岁及以下儿童喘息和医生诊断哮喘的累计患病率及反复咳嗽和喘鸣的点患病率。设计问卷调查，随机抽取按地区当局儿童健康指数登记的儿童进行问卷调查。问卷由家长填写。调查对象为1990年间出生于1985-2009年的1650名白人儿童。主要观察指标：哮喘病和医生诊断哮喘的累计患病率和按年龄和性别划分的咳嗽和反复咳嗽、喘息的点患病率。结果共收到1422份回复(86.2%；男生726份，女生696份)。总体而言，11.0%(95%可信区间9.4%至12.6%)的儿童被正式诊断为哮喘，男孩的累积患病率(12.7%)略高于女孩(9.2%)(年龄调整后的优势比1.47，p=0.03)。1岁以下儿童哮喘累积患病率为7.5%(13/173)，4岁以上儿童为15.9%(61/383)。
Objective-To determine the cumulative prevalences of wheeze and doctor diagnosed asthma and the point prevalences of recurrent cough and wheeze in children aged 5 years and under.Design-Questionnaire survey of population based random sample of children registered on regional authority's child health index for immunisation; questionnaire completed by parents.Setting-Leicestershire.Subjects-1650 white children born in 1985-9 who were surveyed in 1990.Main outcome measures-Cumulative prevalences of wheeze and doctor diagnosed asthma and point prevalences of recurrent cough and wheeze by age and sex.Results-There were 1422 replies (86.2%; 726 for boys, 696 for girls). Overall, 11.0% (95% confidence interval 9.4% to 12.6%) of children had formally been diagnosed as having asthma, the cumulative prevalence in boys (12.7%) being somewhat higher than in girls (9.2%) (age adjusted odds ratio 1.47, p=0.03). As expected, the cumulative prevalence of asthma increased significantly with age (7.5% (13/173) in children under 1 year, 15.9% (61/383) in children of 4 years and over; p