Tacrolimus ointment for the treatment of steroid-induced rosacea: A preliminary report
Tacrolimus ointment for the treatment of steroid-induced rosacea: A preliminary report
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DOI：
10.1067/mjd.2001.114739
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发表时间：
2001-06-01
影响因子：
13.8
通讯作者：
Goldman, D
中科院分区：
文献类型：
--
作者：
Goldman, D
背景：在面部区域过量使用局部皮质类固醇通常会导致类固醇诱发的红斑痤疮。这可能是一个顽固性问题，需要数月的抗生素和抗炎治疗才能解决。目的：本文的目的是回顾他克莫司软膏（一种大环内酯类抗炎软膏）治疗 3 例类固醇引起的红斑痤疮患者的使用情况。方法：3 例类固醇引起的红斑痤疮患者应用他克莫司软膏，0.075%，每日两次，持续 7 至 10 天。还指示患者避免局部使用皮质类固醇和其他加重红斑痤疮的物质，包括咖啡因、辛辣食物、酒精、热液体和氟化物。观察患者的压痛、红斑和瘙痒缓解情况。结果：连续 7 至 10 天使用他克莫司 0.075% 软膏并避免外用类固醇、咖啡因、辛辣食物、酒精、热液体和氟化物后，所有 3 名患者的瘙痒、压痛和红斑均得到缓解。结论：这项初步研究表明他克莫司当避免局部使用类固醇以及避免使用已知会加重红斑痤疮的其他药物（咖啡因、辛辣食物、酒精、热液体和氟化物）时，0.075% 软膏可能对类固醇引起的红斑痤疮患者有效。
Background: Excessive topical corticosteroid application to facial areas commonly leads to steroid-induced rosacea. This may be a recalcitrant problem that requires months of antibiotic and antiinflammatory therapy before it resolves.Objective: The purpose of this article is to review the use of tacrolimus ointment, a macrolide antiinflammatory ointment for the treatment of 3 patients with steroid-induced rosacea.Methods: Three patients with steroid-induced rosacea applied tacrolimus ointment, 0.075% twice daily for 7 to 10 days. Patients were also instructed to avoid topical corticosteroid use and other rosacea-aggravating substances including caffeine, spicy foods, alcohol, hot fluids, and fluoride. Patients were observed for tenderness, erythema, and relief of pruritus.Results: Pruritus, tenderness, and erythema were resolved in all 3 patients after 7 to 10 consecutive days' use of tacrolimus 0.075% ointment in conjunction with a-voidance of topical steroids, caffeine, spicy food, alcohol, hot fluids, and fluoride.Conclusion: This preliminary study demonstrates that tacrolimus 0.075% ointment may be effective for patients with steroid-induced rosacea, when combined with avoidance of topical steroid use, as well as avoidance of other agents known to aggravate rosacea (caffeine, spicy foods, alcohol, hot fluids, and fluoride).