The better effect of Roux-en-Y gastrointestinal reconstruction on blood glucose of nonobese type 2 diabetes mellitus patients
The better effect of Roux-en-Y gastrointestinal reconstruction on blood glucose of nonobese type 2 diabetes mellitus patients
复制标题
Roux-en-Y胃肠重建对非肥胖2型糖尿病患者血糖的较好效果
DOI：
10.1016/j.amjsurg.2013.06.011
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发表时间：
2014-06-01
影响因子：
3
通讯作者：
Hu, Sanyuan
中科院分区：
文献类型：
--
作者：
Chen, Weijie;Yan, Zhibo;Hu, Sanyuan
背景：鉴于胃肠重建的作用，我们研究了Rouxen-Y胃肠重建（RYGR）和Billroth I重建（B1R）是否可以改善非肥胖2型糖尿病患者的血糖。方法：2005年1月至2010年1月期间，我院对76例非肥胖2型糖尿病患者进行了开腹胃大部切除术，RYGR和B1R。除人口统计数据外，还测定了术前体重、血糖、血红蛋白 A1c、生长素释放肽和胰高血糖素样肽 1。 结果：如前所述，35 例 RYGR 患者中 2 例治愈，5 例控制，10 例改善；同样，41 名 B1R 患者中有 2 名得到控制，3 名患者在手术后 12 个月有所改善。 RYGR患者的空腹血糖和血红蛋白A1c下降更为显着(P,.05)。此外，手术后，RYGR 患者的空腹血浆 GLP-1 水平较高，而 B1R 患者的 ghrelin 水平较低 (P < .05)。 结论：RYGR 对非肥胖 2 型糖尿病患者显示出更有效的改善效果。皇冠版权所有 (C) 2014 由 Elsevier Inc. 出版。保留所有权利。
BACKGROUND: Given the role of gastrointestinal reconstruction, we investigated whether Rouxen- Y gastrointestinal reconstruction (RYGR) and Billroth I reconstruction (B1R) can improve glucose in nonobese type 2 diabetes mellitus patients.METHODS: Seventy-six nonobese type 2 diabetes mellitus patients underwent open subtotal gastrectomy with RYGR and B1R between January 2005 and January 2010 in our hospital. Besides demographic data, preoperative weight, glucose, hemoglobin A1c, ghrelin, and glucagon-like peptide 1 were determined.RESULTS: As defined previously, 2 of 35 patients with RYGR were cured, 5 patients were controlled, and 10 patients were improved; similarly, 2 of 41 patients with B1R were controlled, and 3 patients improved 12 months after surgery. The fasting glucose and hemoglobin A1c decreased more significantly in RYGR patients (P,. 05). Moreover, a higher fasting plasma GLP-1 level in RYGR patients and lower ghrelin in B1R patients were noted after surgery (P < .05).CONCLUSIONS: RYGR shows a more effective amelioration in nonobese type 2 diabetes mellitus patients. Crown Copyright (C) 2014 Published by Elsevier Inc. All rights reserved.