Selective Contribution of Regional Adiposity, Skeletal Muscle, and Adipokines to Glucose Disposal in Older Adults
Selective Contribution of Regional Adiposity, Skeletal Muscle, and Adipokines to Glucose Disposal in Older Adults
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DOI：
10.1111/j.1532-5415.2011.03865.x
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发表时间：
2012-04-01
影响因子：
6.3
通讯作者：
Chia, Chee W.
中科院分区：
文献类型：
--
作者：
Ramachandran, Ramona;Gravenstein, Kristofer S.;Chia, Chee W.
目标：研究老年人群中肌肉质量、局部肥胖、脂肪因子和葡萄糖处置之间的关系。设计：横断面分析。背景：来自巴尔的摩老龄化纵向研究的社区志愿者。参与者：280名男性和259名女性，平均年龄为71.1 ± 0.4岁（范围55-96）和空腹血浆脂联素和瘦素、口服葡萄糖耐量试验（OGTT）的完整数据（在0、20、40、60、80、100和120分钟时可获得的血浆葡萄糖）、大腿计算机断层扫描（CT）、身体活动水平和人体测量。参与者根据是否存在全身肥胖被分为八组（体重指数> 27 kg/m2），中心性肥胖（女性腰围> 88 cm，男性腰围> 102 cm），肌肉量低（CT大腿，调整后大腿肌肉面积的最低性别特异性三分位数（女性为93.8 cm（2），男性为110.7 cm（2）。线性回归模型用于估计这八组对早期葡萄糖曲线下面积（AUC）的贡献（t = 0-40分钟），晚期血糖AUC（t = 60-120分钟）和总葡萄糖AUC（t = 0-120分钟）。无论肌肉质量如何，中心性肥胖和全身性肥胖相结合的个体更可能有延迟的葡萄糖处置率（P <0.05）。在循环脂联素水平和葡萄糖处理率之间也发现了很强的负相关（早期AUC，β = -0.14;晚期AUC，β = -0.20;和总AUC，β = -0.20;所有三个AUC的P <0.05）校正局部肥胖、肌肉质量、循环瘦素水平、体力活动、年龄和性别后。全身性和中枢性肥胖的老年人可能有与低肌肉质量无关的葡萄糖耐受不良的风险。J Am Geriatr Soc 60：707-712，2012.
OBJECTIVES: To study the relationships between muscle mass, regional adiposity, and adipokines and glucose disposal in an older population.DESIGN: Cross-sectional analysis.SETTING: Community-dwelling volunteers from the Baltimore Longitudinal Study of Aging.PARTICIPANTS: Two hundred eighty men and 259 women with a mean age of 71.1 +/- 0.4 (range 55-96) and complete data on fasting plasma adiponectin and leptin, oral glucose tolerance test (OGTT) (plasma glucose available at 0, 20, 40, 60, 80, 100, and 120 minutes), thigh computed tomography (CT), physical activity levels, and anthropometric measures.MEASUREMENTS: Participants were classified into eight groups according to the presence of global adiposity (body mass index > 27 kg/m(2)), central adiposity (waist circumference > 88 cm for women and > 102 cm for men), and low muscle mass (CT thigh, lowest sex-specific tertile (93.8 cm(2) in women and 110.7 cm(2) in men) of adjusted thigh muscle area). Linear regression models were used to estimate the contribution of these eight groups to early glucose area under the curve (AUC) (t = 0-40 minutes), late glucose AUC (t = 60-120 minutes), and total glucose AUC (t = 0-120 minutes) from the OGTT.RESULTS: Regardless of muscle mass, individuals with a combination of central and global adiposity were more likely to have delayed glucose disposal rates (P < .05). A strong negative association was also found between circulating adiponectin levels and glucose disposal rates (early AUC, beta = -0.14; late AUC, beta = -0.20; and total AUC, beta = -0.20; P < .05 for all three AUCs) after adjusting for regional adiposity, muscle mass, circulating leptin levels, physical activity, age, and sex.CONCLUSION: Older individuals with global and central adiposity may be at risk of glucose intolerance unrelated to low muscle mass. J Am Geriatr Soc 60:707-712, 2012.