Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System
Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System
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DOI：
10.1177/0192623312454337
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发表时间：
2012-08-01
影响因子：
1.5
通讯作者：
Whitney, Katharine
中科院分区：
文献类型：
--
作者：
Creasy, Dianne;Bube, Axel;Whitney, Katharine
INHAND项目（大鼠和小鼠病变命名和诊断标准国际协调）是欧洲（ESTP）、英国（BSTP）、日本（JSTP）和北美（STP）毒理学病理学会的联合倡议，旨在为实验室动物的增殖性和非增殖性病变制定国际公认的命名法。本出版物的目的是提供一个标准化的命名和鉴别诊断分类显微镜下观察到的病变在雄性生殖系统的实验室大鼠和小鼠，彩色显微照片说明了一些病变的例子。本文件中提出的标准化术语也可供学会成员在互联网上以电子方式查阅（goreni.org）。材料来源包括来自世界各地政府、学术界和工业实验室的组织病理学数据库。内容包括自发性和老化性病变以及暴露于试验材料引起的病变。广泛接受和使用的实验动物雄性生殖系统病变命名的国际协调将减少不同国家的监管和科学研究组织之间的混淆，并提供一种共同语言，以增加和丰富毒理学家和病理学家之间的国际信息交流。
The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the male reproductive system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the Internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the male reproductive system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.