Does dietary intake of vitamins C and E influence lung function in older people?
Does dietary intake of vitamins C and E influence lung function in older people?
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DOI：
10.1164/ajrccm.154.5.8912755
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发表时间：
1996-11-01
影响因子：
24.7
通讯作者：
Holgate, ST
中科院分区：
文献类型：
--
作者：
Dow, L;Tracey, M;Holgate, ST
肺部的抗氧化剂对氧化损伤具有保护作用。我们研究了老年人膳食抗氧化剂的摄入量是否与肺功能有关。根据报告的呼吸道症状，对 178 名 70 岁至 96 岁的男性和女性的抗坏血酸（维生素 C）和 α-生育酚（维生素 E）的膳食摄入量以及肺功能进行了评估。通过多元线性回归调整年龄、性别、身高、吸烟习惯、总能量摄入和维生素 C 摄入量后，维生素 E 摄入量与 FEV(1) p = 0.012 和 FVC p = 0.003 显着相关。没有证据表明维生素 E 摄入量与当前吸烟之间有任何相互作用作为肺功能的决定因素。日常饮食中维生素 E 每增加一毫克，FEV(1) 预计增加 42 毫升，FVC 预计增加 54 毫升。这些结果表明，膳食中维生素E的摄入量可能会影响老年人的肺功能，但本研究中的食物频率调查问卷的敏感性不足以进一步探讨这一假设。
Antioxidants in the lung have a protective role against oxidative damage. We have investigated whether dietary antioxidant intake in elderly people is related to lung function. Dietary intakes of ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E) and lung function were assessed in 178 men and women aged 70 to 96 yr selected on the basis of reported respiratory symptoms. After adjustment for age, gender, height, smoking habits, total energy intake, and vitamin C intake by multiple linear regression, vitamin E intake was significantly associated with FEV(1) p = 0.012 and FVC p = 0.003. There was no evidence of any interaction between vitamin E intake and current tobacco smoking as determinants of lung function. For every extra milligram increase in vitamin E in the daily diet, FEV(1) increased by an estimated 42 ml and FVC by an estimated 54 ml. These results suggest that dietary intake of vitamin E may influence lung function in the elderly, but food frequency questionnaires in this study were not of sufficient sensitivity to explore this hypothesis further.