Longitudinal changes in body composition associated with healthy ageing: men, aged 20-96 years
Longitudinal changes in body composition associated with healthy ageing: men, aged 20-96 years
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DOI：
10.1017/s0007114511003886
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发表时间：
2012-04-14
影响因子：
3.6
通讯作者：
Blair, Steven N.
中科院分区：
文献类型：
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作者：
Jackson, Andrew S.;Janssen, Ian;Blair, Steven N.
肥胖和肌肉减少症是与衰老有关的健康问题。本研究模拟了年龄在20至96岁之间的健康男性身体组成的纵向变化，并评估了BMI的保真度，以确定脂肪量和无脂肪量的年龄依赖性变化。来自7265名男性的多个身体成分测定（总观察38328）的数据被用来模拟与年龄相关的体重，脂肪量，无脂肪质量，BMI和体脂百分比的变化。脂肪质量和去脂肪质量的变化被用来评估BMI的保真度，并检测身体成分随年龄的变化。线性混合回归模型表明，身体成分与健康老龄化的所有轨迹是二次的。脂肪质量、BMI和体脂百分比从20岁开始增加，并在大约80岁时趋于稳定。从20岁到47岁，无脂肪质量略有增加，然后随着年龄的增长以非线性速度下降。有氧运动水平对脂肪量有积极的影响，对去脂量有轻微的负面影响。BMI锌！体脂百分比在检测健康老龄化发生的脂肪量增加方面很敏感，但未能确定47岁开始的无脂肪量损失。
Obesity and sarcopenia are health problems associated with ageing. The present study modelled the longitudinal changes in body composition of healthy men, aged from 20 to 96 years, and evaluated the fidelity of BMI to identify age-dependent changes in fat mass and fat-free mass. The data from 7265 men with multiple body composition determinations (total observations 38 328) were used to model the age-related changes in body mass, fat mass, fat-free mass, BMI and percentage of body fat. Changes in fat mass and fat-free mass were used to evaluate the fidelity of BMI and to detect body composition changes with ageing. Linear mixed regression models showed that all trajectories of body composition with healthy ageing were quadratic. Fat mass, BMI and percentage of body fat increased from age 20 years and levelled off at approximately 80 years. Fat-free mass increased slightly from age 20 to 47 years and then declined at a non-linear rate with ageing. Levels of aerobic exercise had a positive influence on fat mass and a slight negative effect on fat-free mass. BMI zinc! percentage of body fat were sensitive in detecting the increase in fat mass that occurred with healthy ageing, but failed to identify the loss of fat-free mass that started at age 47 years.