Effects of Electronic Cigarette Liquid Nicotine Concentration on Plasma Nicotine and Puff Topography in Tobacco Cigarette Smokers: A Preliminary Report
Effects of Electronic Cigarette Liquid Nicotine Concentration on Plasma Nicotine and Puff Topography in Tobacco Cigarette Smokers: A Preliminary Report
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DOI：
10.1093/ntr/ntv182
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发表时间：
2016-05-01
影响因子：
4.7
通讯作者：
Eissenberg, Thomas
中科院分区：
文献类型：
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作者：
Lopez, Alexa A.;Hiler, Marzena M.;Eissenberg, Thomas
简介：电子香烟（ECIG）雾化的液体通常含有丙二醇和/或植物甘油，香料，以及各种浓度的依赖性药物尼古丁。本研究检查了ECIG液体尼古丁浓度与ECIG未使用过的烟草吸烟者的使用者血浆尼古丁浓度相关的程度。16名未接受过ECIG治疗的吸烟者完成了四个实验室阶段，这些阶段的不同之处在于液体中的尼古丁浓度将所述溶液（0、8、18或36 mg/ml）置于由3.3V电池供电的1.5欧姆双线圈“雾化器”中。在每次会话中，参与者完成两次10次ECIG使用回合，每次呼气间隔30秒;回合间隔60分钟。在每次发作之前和之后采集静脉血用于随后的血浆尼古丁浓度分析;在每次发作期间测量抽吸持续时间、体积和平均流速。在约1中，相对于0 mg/ml尼古丁条件，（平均值= 3.8 ng/ml，SD = 3.3），血浆尼古丁浓度在8次给药后立即显著增加。（平均值= 8.8 ng/ml，SD = 6.3）、18（平均值= 13.2 ng/ml，SD = 13.2）和36 mg/ml（平均值= 17.0 ng/ml，SD = 17.9）液体浓度。在约2次之后观察到类似的模式。与0 mg/ml尼古丁条件相比，36 mg/ml条件下的平均抽吸持续时间显著更短。在第二回合为8和18 mg/ml的conditions.Conclusions：对于一个给定的ECIG设备，尼古丁输送量增加可能直接相关的液体浓度。ECIG初治的吸烟者可以从他们的第一次使用回合，获得与目前可用的ECIG产品类似的尼古丁输送曲线。液体尼古丁浓度可以影响ECIG未使用过的吸烟者的血浆尼古丁浓度，并且在某些浓度下，可以影响具有双线圈的3.3 V ECIG的尼古丁递送曲线，1.5欧姆烟弹雾化器在该人群中接近可燃烟草香烟的雾化器。正如我们在这里报告的那样，找到一种能像烟草香烟一样有效地释放尼古丁的产品，对于那些想用ECIG完全取代可燃烟草香烟的吸烟者来说可能是至关重要的。
Introduction: Electronic cigarettes (ECIGs) aerosolize a liquid that usually contains propylene glycol and/or vegetable glycerin, flavorants, and the dependence-producing drug nicotine in various concentrations. This study examined the extent to which ECIG liquid nicotine concentration is related to user plasma nicotine concentration in ECIG-naive tobacco cigarette smokers.Methods: Sixteen ECIG-naive cigarette smokers completed four laboratory sessions that differed by the nicotine concentration of the liquid (0, 8, 18, or 36 mg/ml) that was placed into a 1.5 Ohm, dual coil "cartomizer" powered by a 3.3 V battery. In each session, participants completed two, 10-puff ECIG use bouts with a 30-second inter-puff interval; bouts were separated by 60 minutes. Venous blood was sampled before and after bouts for later analysis of plasma nicotine concentration; puff duration, volume, and average flow rate were measured during each bout.Results: In bout 1, relative to the 0 mg/ml nicotine condition (mean = 3.8 ng/ml, SD = 3.3), plasma nicotine concentration increased significantly immediately after the bout for the 8 (mean = 8.8 ng/ml, SD = 6.3), 18 (mean = 13.2 ng/ml, SD = 13.2), and 36 mg/ml (mean = 17.0 ng/ml, SD = 17.9) liquid concentration. A similar pattern was observed after bout 2. Average puff duration in the 36 mg/ml condition was significantly shorter compared to the 0 mg/ml nicotine condition. Puff volume increased during the second bout for 8 and 18 mg/ml conditions.Conclusions: For a given ECIG device, nicotine delivery may be directly related to liquid concentration. ECIG-naive cigarette smokers can, from their first use bout, attain cigarette-like nicotine delivery profiles with some currently available ECIG products.Implications: Liquid nicotine concentration can influence plasma nicotine concentration in ECIG-naive cigarette smokers, and, at some concentrations, the nicotine delivery profile of a 3.3 V ECIG with a dual coil, 1.5-Ohm cartomizer approaches that of a combustible tobacco cigarette in this population. Finding a product that delivers nicotine as effectively as a tobacco cigarette, as we report here, may be essential for smokers who want to replace completely their combustible tobacco cigarettes with ECIGs.