Linguistic ability in early life and the neuropathology of Alzheimer's disease and cerebrovascular disease - Findings from the nun study
Linguistic ability in early life and the neuropathology of Alzheimer's disease and cerebrovascular disease - Findings from the nun study
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DOI：
10.1111/j.1749-6632.2000.tb06347.x
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发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
Markesbery, WR
中科院分区：
文献类型：
--
作者：
Snowdon, DA;Greiner, LH;Markesbery, WR
修女研究的结果表明，早年语言能力低下与晚年痴呆和过早死亡密切相关。在本研究中，我们研究了早期语言能力与阿尔茨海默病和脑血管疾病的神经病理学的关系。这些分析是针对修女研究中的 74 名参与者进行的，我们为他们手写了自传，年龄在 19 岁到 37 岁之间（平均 = 23 个恐惧）。平均在写完自传 62 年后，当参与者的年龄在 78 岁到 97 岁之间时，他们就会死亡，并且他们的大脑被摘除用于我们的神经病理学研究。早期生活的语言能力是通过自传的思想（命题）密度来衡量的，即文本样本中思想内容的标准衡量标准。早年的想法密度评分与阿尔茨海默病病理学的严重程度呈强烈的负相关。 在新皮质中：想法密度评分与神经原纤维缠结计数之间的相关性，额叶为 -0.59，颞叶为 -0.48，顶叶为 -0.49（所有 p 值 < 0.0001）。想法密度评分与大脑底部主要动脉粥样硬化的严重程度以及腔隙性和大面积脑梗塞的存在无关。早期语言能力低可能反映了神经和认知发育欠佳，这可能会增加晚年阿尔茨海默氏病病理学发展的易感性。
Findings from the Nun Study indicate that low linguistic ability in early life has a strong association with dementia and premature death in late life. In the present study, we investigated the relationship of linguistic ability in early life to the neuropathology of Alzheimer's disease and cerebrovascular disease. The analyses were done on a subset of 74 participants in the Nun Study for whom we had handwritten autobiographies completed some time between the ages of 19 and 37 (mean = 23 fears). An average of 62 years after writing the autobiographies, when the participants were 78 to 97 years old, they died and their brains were removed for our neuropathologic studies. Linguistic ability in early life was measured by the Idea (proposition) density of the autobiographies, i.e., a standard measure of the content of ideas in text samples. Idea density scores from early life had strong inverse correlations with the severity of Alzheimer's disease pathology In the neocortex: Correlations between idea density scores and neurofibrillary tangle counts were -0.59 for the frontal lobe, -0.48 for the temporal lobe, and -0.49 for the parietal lobe (all p values < 0.0001). Idea density scores were unrelated to the severity of atherosclerosis of the major arteries at the base of the brain and to the presence of lacunar and large brain infarcts, Low linguistic ability in early life may reflect suboptimal neurological and cognitive development, which might increase susceptibility to the development of Alzheimer's disease pathology in late life.