A high-fat diet has sex-specific effects on nicotine vapor self-administration in mice.
A high-fat diet has sex-specific effects on nicotine vapor self-administration in mice.
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DOI：
10.1016/j.drugalcdep.2022.109694
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发表时间：
2022-12-01
影响因子：
4.2
通讯作者：
Cooper, Skylar Y.
中科院分区：
文献类型：
--
作者：
Henderson, Brandon J.;Richardson, Montana R.;Cooper, Skylar Y.
先前的研究表明，富含脂肪的饮食会增加对药物依赖的脆弱性，包括尼古丁。尽管有这些知识，但对神经化学机制的研究很少完成。我们的目的是研究高脂肪饮食（HFD）是否影响尼古丁摄入，同时研究多巴胺信号的潜在变化。成年雄性和雌性C57/BL6J小鼠在维持标准饮食或HFD 6周后进行尼古丁e-vape®自我给药（EVSA）测定。在另一组小鼠中，用快速扫描循环伏安法检测伏隔核的多巴胺释放。与标准饮食小鼠相比，被分配到HFD的雌性小鼠在低努力反应（FR1）期间表现出更高的尼古丁EVSA。hfd分配小鼠（雄性和雌性）在递进比例任务中也表现出较少的主动鼻子戳。最后，与标准饮食小鼠相比，hfd小鼠表现出减少的阶段性多巴胺释放。这些研究表明，富含脂肪的饮食改变了尼古丁的摄入量（雌性在低努力时增加，雄性和雌性在高努力时减少），这可能是由于hfd引起的NAc多巴胺释放减少。
Previous investigations have shown that fat-rich diets increase vulnerability to drug dependence, including nicotine. Despite this knowledge, few investigations into the neurochemical mechanisms have been completed. Our objective here was to examine if high-fat diet (HFD) impacted nicotine intake and in parallel examine potential changes in dopamine signaling. Adult male and female C57/BL6J mice were used in nicotine e-vape® self-administration (EVSA) assays after being maintained on a standard diet or HFD for 6 weeks. In a separate cohort of mice, dopamine release in the nucleus accumbens core was examined with fast-scan cyclic voltammetry. Female mice assigned to HFD exhibited increased nicotine EVSA during low-effort responding (FR1) when compared to standard-diet mice. HFD-assigned mice (male and female) also exhibited reduced active nose pokes in a progressive ratio task. Finally, HFD-mice exhibited reduced phasic dopamine release compared to standard-diet mice. These show that fat-rich diets alter nicotine intake (females increase at low effort, males and females decrease at high effort) and this may occur due to HFD-induced decreases in NAc dopamine release.
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影响因子：
4.7
作者：
Cruz B;Carcoba LM;Flores RJ;Espinoza EJ;Nazarian A;O'Dell LE
通讯作者：
O'Dell LE
影响因子：
4.7
作者：
Avelar, Alicia J.;Akers, Austin T.;Henderson, Brandon J.
通讯作者：
Henderson, Brandon J.
影响因子：
3.7
作者：
Cone JJ;Chartoff EH;Potter DN;Ebner SR;Roitman MF
通讯作者：
Roitman MF
尼古丁制剂会影响蒸汽自我给药的小鼠模型中与增强相关的行为。
影响因子：
4.2
作者：
Henderson BJ;Cooper SY
通讯作者：
Cooper SY
影响因子：
4.7
作者：
Cruz, Bryan;Ortegon, Sebastian;Giner, Priscilla;Matos-Ocasio, Felix;Rodriguez-Crespo, Andrea;Uribe, Kevin P.;Galindo, Kayla, I;Serafine, Katherine M.;Nazarian, Arbi;O'Dell, Laura E.
通讯作者：
O'Dell, Laura E.