Gender difference in relationship between anxiety-related personality traits and cerebral brain glucose metabolism
Gender difference in relationship between anxiety-related personality traits and cerebral brain glucose metabolism
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DOI：
10.1016/j.pscychresns.2008.10.002
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发表时间：
2009-09-30
影响因子：
2.3
通讯作者：
Inada, Toshiya
中科院分区：
文献类型：
--
作者：
Hakamata, Yuko;Iwase, Mikio;Inada, Toshiya
最近的功能神经成像研究表明，特定的大脑区域可能与焦虑相关个性特征的形成有关，众所周知，这些个性特征受到性别的影响。这种与焦虑相关的人格特征是情绪和焦虑症的典型易感因素之一，其发生率也被认为受到性别的很大影响。然而，与焦虑相关的人格特征相关的大脑功能的性别差异却知之甚少。本研究的目的是检验焦虑相关人格特征与大脑葡萄糖代谢之间关系模式的性别差异。用[F-18]氟脱氧葡萄糖正电子发射断层扫描对102例健康受试者(男65例，女37例)进行了局部脑葡萄糖代谢测定。焦虑相关特质使用气质和性格问卷维度的伤害避免(HA)进行评估。女性前额叶腹内侧皮质(VmPFC)前部透明质酸与糖代谢呈负相关，而男性则无相关关系。前部vmPFC可能是预防或治疗情绪障碍，尤其是女性情绪障碍的神经靶点。(C)2008爱思唯尔爱尔兰有限公司。保留所有权利。
Recent functional neuroimaging studies have suggested that specific brain regions might be associated with the formation of anxiety-related personality traits, which are well known to be influenced by gender. Such anxiety-related personality traits are one of the representative predisposing factors for mood and anxiety disorders, whose incidence is also known to be much influenced by gender. However, little is known about the gender differences in brain function related to anxiety-related personality traits. The aim of the present study was to examine gender-related differences in the pattern of the relationships between an anxiety-related personality trait and cerebral brain glucose metabolism. Regional brain glucose metabolism was measured using [F-18]fluorodeoxyglucose positron emission tomography in 102 healthy subjects (65 males and 37 females). An anxiety-related trait was assessed using the Temperament and Character Inventory dimension Harm Avoidance (HA). HA was negatively correlated with glucose metabolism in the anterior portion of the ventromedial prefrontal cortex (vmPFC) in females but not in males. The anterior vmPFC may be a possible neural target for the prevention or therapy of emotional disorders, especially in females. (C) 2008 Elsevier Ireland Ltd. All rights reserved.