The roles of the lateral intraparietal area and frontal eye field in guiding eye movements in free viewing search behavior.
The roles of the lateral intraparietal area and frontal eye field in guiding eye movements in free viewing search behavior.
复制标题
外侧顶叶区和额叶视野在自由观看搜索行为中引导眼球运动的作用。
DOI：
10.1152/jn.00559.2020
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发表时间：
2021
影响因子：
2.5
通讯作者：
Bisley,JamesW
中科院分区：
文献类型：
--
作者：
Mirpour,Koorosh;Bisley,JamesW
侧顶内区（LIP）和额眼区（FEF）已被证明在动眼病控制中起重要作用，但大多数研究发现这两个区域的行为相似。为了确定每个区域在指导眼球运动中所起的独特作用，我们记录了4只执行自由观看视觉觅食任务的动物的200个LIP神经元和231个FEF神经元。我们分析了神经元的反应是如何被刺激物的身份和动物选择的位置所调节的。我们还分析了感觉信号和选择信号的调制，以确定感觉信号是如何驱动选择的。我们发现了一个明确的分工：LIP提供了一个整合任务规则和刺激同一性的稳定映射，而FEF反应是动态的，代表了更复杂的信息，并且在扫视之前，与任务规则和刺激同一性相结合，以决定眼睛移动到哪里。众所周知，侧资本内区（LIP）和额眼区（FEF）有助于指导眼球运动，但人们对这两个区域所起的独特作用知之甚少。通过一个自由观看的视觉搜索任务，我们发现LIP提供了一个稳定的视觉世界地图，整合了任务规则和刺激身份。FEF活动一直受到更复杂信息的调节，但是，在扫视之前，FEF会整合所有信息，以做出关于移动位置的最终决定。
The lateral intraparietal area (LIP) and frontal eye field (FEF) have been shown to play significant roles in oculomotor control, yet most studies have found that the two areas behave similarly. To identify the unique roles each area plays in guiding eye movements, we recorded 200 LIP neurons and 231 FEF neurons from four animals performing a free viewing visual foraging task. We analyzed how neuronal responses were modulated by stimulus identity and the animals’ choice of where to make a saccade. We additionally analyzed the comodulation of the sensory signals and the choice signal to identify how the sensory signals drove the choice. We found a clearly defined division of labor: LIP provided a stable map integrating task rules and stimulus identity, whereas FEF responses were dynamic, representing more complex information and, just before the saccade, were integrated with task rules and stimulus identity to decide where to move the eye.NEW & NOTEWORTHY The lateral intrapareital area (LIP) and frontal eye field (FEF) are known to contribute to guiding eye movements, but little is known about the unique roles that each area plays. Using a free viewing visual search task, we found that LIP provides a stable map of the visual world, integrating task rules and stimulus identity. FEF activity is consistently modulated by more complex information but, just before the saccade, integrates all the information to make the final decision about where to move.