Abnormalities in electrocardiographic ventricular repolarization in patients with dengue virus infection
Abnormalities in electrocardiographic ventricular repolarization in patients with dengue virus infection
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DOI：
10.3855/jidc.10746
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发表时间：
2019-08-01
影响因子：
1.9
通讯作者：
Bestetti, Reinaldo Bulgarelli
中科院分区：
文献类型：
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作者：
Furlan-Daniel, Rosemary Aparecida;Silveira Santos, Luis Felipe;Bestetti, Reinaldo Bulgarelli
简介：登革病毒感染（DENV）是一种虫媒病毒疾病，每年影响世界许多国家的数百万人。这种疾病是由蚊子（埃及伊蚊和/或白纹伊蚊）叮咬引起的。在这种虫媒病毒疾病中观察到的症状/体征是非特异性的，血细胞计数通常显示白细胞减少症和血小板减少症。尽管在DENV中可以观察到ECG变化，但对患有这种疾病的患者的心室复极参数知之甚少。因此，本研究的目的是评估QTc和QT间期离散度，以检测心室复极变化的患者与DENV。方法：93个连续的患者在DENV流行期间在一个小镇与非复杂的DENV被包括在内; 93个正常人作为对照。临床资料，血细胞计数和12导联心电图从每个individual.Results：QTc间期较高，在DENV患者相比，对照组。此外，5%的DENV患者QTc间期异常延长。DENV患者和对照组之间QT间期离散度无差异。结论：DENV患者存在心肌复极改变。考虑到这些变化对患者结局的潜在影响，并且由于在我国DENV的情况下不常规推荐12导联ECG，因此我们建议在DENV流行期间对每位患有这种疾病的患者进行12导联ECG。
Introduction: Dengue virus infection (DENV) is an arboviral disease that affects millions of people in many countries throughout the world every year. The disease is caused by the bite of a mosquito (Aedes aegypti and / or Aedes albopictus). The symptoms/signs observed in this arboviral disease are unspecific, and the blood count usually shows leukopenia and thrombocytopenia. Although ECG changes may be observed in DENV, little is known about parameters of ventricular repolarization in patients with this condition. Accordingly, the aim of this study was to evaluate the QTc and QT interval dispersion to detect ventricular repolarization changes in patients with DENV.Methodology: Ninety-three consecutive patients seen during DENV epidemics in a small town with non-complicated DENV were included; 93 normal individuals served as controls. Clinical data, blood count and the 12-lead ECG were obtained from each individual.Results: The QTc duration was higher in patients with DENV in comparison to controls. Furthermore, 5% of DENV patients had abnormal lengthening of the QTc interval. No difference regarding QT interval dispersion was observed between DENV patients and controls. No DENV patient had increased lengthening of the QT interval dispersion.Conclusions: Myocardial repolarization changes do occur in patients with DENV. Having into account the potential impact of these changes on patients' outcome, and because 12-lead ECG is not routinely recommended in the setting of DENV in our country, we recommend that a 12-lead ECG be taken from each patient with this condition during DENV epidemics.