GATA transcription factors in adrenal development and tumors
GATA transcription factors in adrenal development and tumors
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DOI：
10.1016/j.mce.2006.12.033
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发表时间：
2007-02
影响因子：
4.1
通讯作者：
H. Parviainen;S. Kiiveri;M. Bielińska;N. Rahman;I. Huhtaniemi;D. Wilson;M. Heikinheimo
中科院分区：
文献类型：
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作者：
H. Parviainen;S. Kiiveri;M. Bielińska;N. Rahman;I. Huhtaniemi;D. Wilson;M. Heikinheimo
在六种加塔转录因子中，加塔-4和加塔-6在小鼠和人肾上腺中表达，具有不同的发育特征。加塔-4局限于胎儿皮质，即局限于分化程度较低的增殖细胞，而加塔-6在胎儿和成人肾上腺中都表达。在体外，加塔-4调节与正常肾上腺功能有关的α-肾上腺素和类固醇生成因子-1。加塔-6可能在肾上腺皮质细胞的发育和分化以及类固醇生成的调节中发挥作用。在促性腺激素依赖性小鼠肾上腺皮质肿瘤中，加塔-4表达显著上调，而加塔-6表达下调。这是伴随着黄体生成素受体（LHR）的出现。在体外，加塔-4反式激活LHR启动子，促性腺激素上调加塔-4水平。人肾上腺肿瘤偶尔表达加塔-4，而加塔-6水平通常低于正常。
Of the six GATA transcription factors, GATA-4 and GATA-6 are expressed in the mouse and human adrenal with distinct developmental profiles. GATA-4 is confined to the fetal cortex, i.e. to the less differentiated proliferating cells, while GATA-6 is expressed both in the fetal and adult adrenal. In vitro, GATA-4 regulates inhibin-α and steroidogenic factor-1 implicated in normal adrenal function. GATA-6 probably has roles in the development and differentiation of adrenocortical cells, and in the regulation of steroidogenesis. GATA-4 expression is dramatically upregulated and GATA-6 downregulated in gonadotropin dependent mouse adrenocortical tumors. This is accompanied by the appearance of luteinizing hormone receptor (LHR). In vitro, GATA-4 transactivates LHR promoter, and gonadotropins upregulate GATA-4 levels. Human adrenal tumors occasionally express GATA-4, whereas GATA-6 levels are usually lower than normal.