RIFINs are adhesins implicated in severe Plasmodium falciparum malaria
RIFINs are adhesins implicated in severe Plasmodium falciparum malaria
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DOI：
10.1038/nm.3812
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发表时间：
2015-04-01
期刊：
影响因子：
82.9
通讯作者：
Wahlgren, Mats
中科院分区：
文献类型：
--
作者：
Goel, Suchi;Palmkvist, Mia;Wahlgren, Mats
玫瑰花结是一种恶性疟原虫现象，与严重疟疾有关。在这里，我们证明了恶性疟原虫编码的重复散布的多肽家族（RIFIN）在感染的红细胞（iRBC）的表面上表达，与RBC结合，优先与A型血的RBC结合，以形成大的roblocks，并介导iRBC的微血管结合。我们认为RIFIN在严重疟疾的发展中发挥着根本性作用，从而导致全球人群中ABO血型的不同分布。
Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.