Malignant lymphoma of the breast. Immunologic type and association with lymphocytic mastopathy.
Malignant lymphoma of the breast. Immunologic type and association with lymphocytic mastopathy.
复制标题
乳房恶性淋巴瘤。
DOI：
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发表时间：
1992
影响因子：
3.5
通讯作者：
Tadahiro Taguchi
中科院分区：
文献类型：
--
作者：
K. Aozasa;M. Ohsawa;K. Saeki;K. Horiuchi;K. Kawano;Tadahiro Taguchi
本文回顾了日本几家医院收集的19例乳腺原发性非霍奇金淋巴瘤的临床和病理资料。所有患者均为女性（中位年龄45岁），她们通常有近期增大的乳房肿块。病变部位为右乳8例，左乳8例，双乳1例。两个群众的位置是未知的。术后14、23和23个月，3例对侧乳房淋巴瘤复发。组织学上，弥漫性大细胞淋巴瘤是最常见的疾病形式（63%）。一处病变为滤泡性淋巴瘤。在8例（42%）中观察到所谓的淋巴上皮病变，这是粘膜相关淋巴组织型淋巴瘤的特征性发现。免疫组化分析显示，所有的，但两个肿瘤的B细胞型，这些发现证实了形态学为基础的结论。淋巴细胞性乳腺病，最近描述的自身免疫性疾病的乳房，组织学和免疫组化证据，发现在大多数情况下。5例（26%）瘤内或瘤周有淋巴滤泡形成。基于这些发现，我们认为大多数乳腺淋巴瘤是B细胞肿瘤，它们可能与并存或先发的淋巴细胞性乳腺病有关。
Clinical and pathologic findings in 19 cases of primary non-Hodgkin's lymphoma of the breast collected from several hospitals in Japan were reviewed. All patients were women (median age, 45 years) and they usually had breast masses that had recently become enlarged. The sites of the lesions were the right breast in eight cases, the left breast in eight, and both breasts in one. The locations of two masses were unknown. Lymphoma recurred in the opposite breast in three cases 14, 23, and 23 months after surgery. Histologically, diffuse large cell lymphoma was the most common form of disease (63%). One lesion was a follicular lymphoma. The so-called lymphoepithelial lesion, a characteristic finding for mucosa-associated lymphoid tissue type lymphomas, was observed in eight cases (42%). Immunohistochemical analysis revealed that all but two tumors were of B-cell type; such findings confirmed morphologically based conclusions. Histologic and immunohistochemical evidence of lymphocytic mastopathy, a recently described autoimmune disease of the breast, was found in most of the cases. Formation of lymphoid follicles in or around the tumors was found in five cases (26%). Based on these findings, it is suggested that most mammary lymphomas are B-cell tumors and they may be associated with coexisting or antecedent lymphocytic mastopathy.
影响因子：
11.2
作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana
通讯作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana