Noninvasive monitoring of a murine model of metastatic pheochromocytoma: a comparison of contrast-enhanced microCT and nonenhanced MRI.
Noninvasive monitoring of a murine model of metastatic pheochromocytoma: a comparison of contrast-enhanced microCT and nonenhanced MRI.
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DOI：
10.1002/jmri.21654
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发表时间：
2009-03
影响因子：
4.4
通讯作者：
Pacak, Karel
中科院分区：
文献类型：
--
作者：
Martiniova, Lucia;Kotys, Melanie S.;Thomasson, David;Schimel, Daniel;Lai, Edwin W.;Bernardo, Marcelino;Merino, Maria J.;Powers, James F.;Ruzicka, Jan;Kvetnansky, Richard;Choyke, Peter L.;Pacak, Karel
目的：在转移性嗜铬细胞瘤动物模型中比较增强显微计算机断层扫描(MicroCT)和非增强呼吸触发磁共振成像(MRI)。动物模型在癌症治疗研究中正变得越来越重要，而成像在最大限度地减少所需动物数量和降低尸检相关成本方面是有用的。然而，成像方式的选择仍在不断发展。成年雌性裸鼠经尾静脉注射小鼠嗜铬细胞瘤(MPC)细胞系(MPC 4/30PRR)建立转移模型。在优化了成像技术后，8只小鼠同时进行了呼吸触发磁共振成像和显微CT成像，结果得到了组织学上的证实。在大小为350μm的阈值下，MicroCT和MRI发现肝转移瘤的能力大致相同。在肺部，MRI比MicroCT更敏感，发现直径为0.6 mm的病变，而MicroCT为1 mm。此外，MRI对肾脏、骨骼、卵巢和肾上腺的病变更敏感。MRI显示的对比度噪声比(CNR)高于MicroCT。除了不将动物暴露在电离辐射下的优势外，与MicroCT相比，MRI还提供了对该模型中转移程度的更完整的评估。
To compare contrast-enhanced micro computed tomography (microCT) and non-enhanced respiratory-triggered MRI in an animal model of metastatic pheochromocytoma. Animal models are becoming important in the study of cancer treatment and imaging is useful in minimizing the number of animals needed and reducing costs associated with autopsies. However, the choice of imaging modality is still evolving. Adult female nude mice were injected by tail vein with a mouse pheochromocytoma (MPC) cell line (MPC 4/30PRR) to create a metastatic model. After optimizing imaging techniques eight mice were imaged with both respiratory triggered MRI and microCT and the findings were verified histologically. MicroCT and MRI were approximately equal in their ability to detect hepatic metastases at a size threshold of 350 μm. In the lungs, MRI was more sensitive than microCT, detecting lesions 0.6 mm in diameter vs. 1mm for microCT. Additionally, MRI was more sensitive for lesions in the kidneys, bone, ovaries and adrenal glands. MRI demonstrated higher contrast-to-noise ratio (CNR) than microCT. In addition to the advantage of not exposing the animal to ionizing radiation, MRI provided a more complete assessment of the extent of metastases in this model, compared to microCT.
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影响因子：
4.6
作者：
Ohta, Shoichiro;Lai, Edwin W.;Pacak, Karel
通讯作者：
Pacak, Karel
影响因子：
1.9
作者：
Payne, JT
通讯作者：
Payne, JT
影响因子：
7.3
作者：
WEICHERT, JP;LONGINO, MA;COUNSELL, RE
通讯作者：
COUNSELL, RE
影响因子：
9
作者：
Goldstein, RE;O'Neill, JA;Scott, HW
通讯作者：
Scott, HW
影响因子：
3.6
作者：
Powers, JF;Evinger, MJ;Tischler, AS
通讯作者：
Tischler, AS