Prurigo Nodularis Management
Prurigo Nodularis Management
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DOI：
10.1159/000446049
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Staender, Sonja
中科院分区：
文献类型：
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作者：
Tsianakas, Athanasios;Zeidler, Claudia;Staender, Sonja
结节性痒疹（PN）的临床表现是个体多发、对称分布、角化过度、剧烈瘙痒的丘疹和结节，是一种罕见疾病，多见于因长期持续搔抓而导致慢性瘙痒的患者。皮损处的瘙痒和抓挠会造成恶性循环，使这种疾病难以治疗，从而降低患者的生活质量。尽管涉及免疫神经元串扰，但 PN 的发病机制尚不明确。发现其病因具有异质性。它可以作为各种皮肤病、神经病、精神病和全身性疾病的症状出现。目前尚无批准的 PN 治疗方法。然而，当代疗法包括钙调神经磷酸酶抑制剂、辣椒素、局部类固醇、紫外线疗法以及抗组胺药、抗惊厥药、μ阿片受体拮抗剂和免疫抑制剂的全身应用。为了达到最佳效果，应采用多模式治疗，包括局部和全身对症治疗。 (C) 2016 S. Karger AG，巴塞尔
Characterized by the clinical presentation of individual to multiple symmetrically distributed, hyperkeratotic, and intensely itchy papules and nodules, prurigo nodularis (PN) is a rare disease that emerges in patients with chronic pruritus due to continuous scratching over a long period of time. The itching and scratching of the lesions contribute to the vicious cycle that makes this disease difficult to treat, thus reducing the quality of life of affected patients. The pathogenesis of PN is ambiguous, although immunoneuronal crosstalk is implicated. Its etiology was found to be heterogenous. It can emerge as the symptom of various dermatological, neurological, psychiatric, and systemic diseases. There is currently no approved therapy for PN. However, contemporary therapies consist of calcineurin inhibitors, capsaicin, topical steroids, UV therapy, and a systemic application of antihistamines, anticonvulsants, mu-opioid receptor antagonists, and immunosuppressants. Multimodal therapy should be utilized in order to achieve optimal results, including topical and systemic symptomatic therapies. (C) 2016 S. Karger AG, Basel