Influenza B associated paediatric acute respiratory infection hospitalization in central vietnam
Influenza B associated paediatric acute respiratory infection hospitalization in central vietnam
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DOI：
10.1111/irv.12626
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发表时间：
2019-05-01
影响因子：
4.4
通讯作者：
Yoshida, Lay-Myint
中科院分区：
文献类型：
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作者：
Yoshihara, Keisuke;Minh Nhat Le;Yoshida, Lay-Myint
背景B型流感是全球儿童急性呼吸道感染（ARI）的主要病因之一，但其临床流行病学信息有限。我们的目的是调查越南中部乙型流感相关的儿科阿里斯的住院发病率和临床流行病学特征。方法我们收集了2007年2月至2013年6月在越南芽庄庆和总医院住院的ARI儿童的临床流行病学信息和鼻咽拭子。使用多重PCR筛选鼻咽样品中的13种呼吸道病毒。通过血凝素基因测序对乙型流感确诊病例进行基因分型。我们分析了流感B谱系（维多利亚/山形）和WHO组的临床流行病学特征。结果在甲型H1N1 pdm 09流感爆发前，5岁以下儿童中乙型流感相关ARI住院率较低，为14.7 ~ 80.7/10万。在甲型H1N1 pdm 09之后，发病率增加到51.4至330之间。B型流感急性呼吸道感染病例年龄稍大，症状较轻。维多利亚和Yamagata谱系在A/H1N1 pdm 09爆发之前都被检测到;然而，维多利亚谱系在2010-2013年成为主要谱系（84%维多利亚vs 16% Yamagata）。维多利亚和山形血统在人口统计学和临床特征方面没有差异。在维多利亚谱系中，第1组ARI病例的临床严重程度高于第5组，表现为喘息、呼吸急促和下呼吸道感染的比例更高。结论目前的研究结果强调了甲型H1N1 pdm 09流感后越南中部儿童中乙型流感相关ARI住院的发病率增加。此外，维多利亚谱系组1和5之间临床严重程度的差异表明流感B遗传变异对临床表现的重要性。
Background Influenza B is one of the major etiologies for acute respiratory infections (ARI) among children worldwide; however, its clinical-epidemiological information is limited. We aimed to investigate the hospitalization incidence and clinical-epidemiological characteristics of influenza B-associated paediatric ARIs in central Vietnam. Methods We collected clinical-epidemiological information and nasopharyngeal swabs from ARI children hospitalized at Khanh Hoa General Hospital, Nha Trang, Vietnam from February 2007 through June 2013. Nasopharyngeal samples were screened for 13 respiratory viruses using Multiplex-PCRs. Influenza B-confirmed cases were genotyped by Haemagglutinin gene sequencing. We analyzed the clinical-epidemiological characteristics of influenza B Lineages (Victoria/Yamagata) and WHO Groups. Results In the pre-A/H1N1pdm09 period, influenza B-associated ARI hospitalization incidence among children under five was low, ranging between 14.7 and 80.7 per 100 000 population. The incidence increased to between 51.4 and 330 in the post-A/H1N1pdm09. Influenza B ARI cases were slightly older with milder symptoms. Both Victoria and Yamagata lineages were detected before the A/H1N1pdm09 outbreak; however, Victoria lineage became predominant in 2010-2013 (84% Victoria vs 16% Yamagata). Victoria and Yamagata lineages did not differ in demographic and clinical characteristics. In Victoria lineage, Group1 ARI cases were clinically more severe compared to Group5, presenting a greater proportion of wheeze, tachypnea, and lower respiratory tract infection. Conclusions The current results highlight the increased incidence of influenza B-related ARI hospitalization among children in central Vietnam in the post-A/H1N1pdm09 era. Furthermore, the difference in clinical severity between Victoria lineage Group1 and 5 implies the importance of influenza B genetic variation on clinical presentation.