Prevalence and Presentation of Hepatitis B and C Virus (HBV and HCV) Infection in Vietnamese Americans via Serial Community Serologic Testing
Prevalence and Presentation of Hepatitis B and C Virus (HBV and HCV) Infection in Vietnamese Americans via Serial Community Serologic Testing
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DOI：
10.1007/s10903-013-9975-5
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发表时间：
2015-02-01
影响因子：
1.9
通讯作者：
Hu, Ke-Qin
中科院分区：
文献类型：
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作者：
Kelvin Nguyen;Thai Van Nguyen;Hu, Ke-Qin
据报道，在越南裔美国人(VAS)中，乙肝病毒(HBV)感染的流行率很高，但以前的大多数研究都没有评估完整的乙肝病毒血清学，也没有同时评估乙肝病毒和丙型肝炎病毒(HCV)感染的流行率。这项研究的目的是评估不同的乙肝病毒血清和丙型肝炎病毒感染在VAS中的流行率。本研究基于加利福尼亚州奥兰治县VAS一系列社区筛查中乙肝表面抗原(HBs)、抗乙肝核心抗体(HBcAb)、抗-HBs抗体(抗-HBs)和抗-丙型肝炎抗体(抗-HCV)检测结果。在1,405名退伍军人中，平均年龄为51岁(17-87岁)，其中45.1%为男性，68.2%已婚，97.2%出生在越南。大多数参与者都是非美国出生的人，他们的主要语言是非英语，获得医疗保健的机会有限。在1405例患者中，有124例(8.8%)为乙肝表面抗原阳性，81例(5.8%)为抗-丙型肝炎病毒阳性，其中4例(0.3%)为乙肝病毒/丙型肝炎病毒混合感染。在确诊为乙肝病毒感染的参与者中，12%的人认为他们之前的检测结果为阴性，而在确认为丙型肝炎病毒感染的参与者中，有29.7%的人认为他们之前的检测结果为阴性。在这一队列中，15.4%的人是HBs Ag/HBs Ab-/HBcAbIg-，即对乙肝病毒感染易感。在感染丙型肝炎病毒的参与者中，65.4%的人出生于1945年至1965年之间。这项在越南裔美国人社区进行的大型系列调查和筛查证实，乙肝病毒和丙型肝炎病毒的感染率分别高达8.8%和5.8%。我们还确定了与高危人群中的乙肝病毒和丙型肝炎病毒感染相关的因素。
The prevalence of hepatitis B virus (HBV) infection is reportedly high in Vietnamese Americans (VAs), but most previous studies did not assess full HBV serology, and not the prevalence of HBV and hepatitis C virus (HCV) infection simultaneously. The aim of the study is to assess the prevalence of different HBV serologies and HCV infection in VAs. This study was based on the data collected by testing for Hepatitis B surface antigen (HBsAg), anti-hepatitis B core antibody (HBcAb IgG), anti-HBs antibody (HBsAb), and anti-HCV antibody (anti-HCV) in a series of community screening in VAs in Orange County, California. In 1,405 VA participants, the mean age was 51 (17-87) years, 45.1 % were males; 68.2 %, married; 97.2 %, born in Vietnam. Most of the participants were non-US born with their primary language being non-English and with limited access to health care. Of the 1,405 cases, 124 (8.8 %) were confirmed HBV infection by HBsAg+; 81 (5.8 %), HCV infection by anti-HCV+; including four (0.3 %) with HBV/HCV coinfection. Twelve percent of the participants with confirmed HBV infection thought they were previously tested negative, while 29.7 % of the participants with confirmed HCV infection thought they were previously tested negative. In this cohort, 15.4 % were HBsAg-/HBsAb-/HBcAb IgG-, i.e. being susceptible to HBV infection. In HCV infected participants, 65.4 % were born between 1945 and 1965. This large serial survey and screening in the Vietnamese American community confirmed the rates of HBV and HCV infection to be as high as 8.8 % and 5.8 %, respectively. We have also identified factors related to HBV and HCV infection in this high-risk population.