Liquid-ordered phases induced by cholesterol: A compendium of binary phase diagrams
Liquid-ordered phases induced by cholesterol: A compendium of binary phase diagrams
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DOI：
10.1016/j.bbamem.2009.12.027
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发表时间：
2010-03-01
影响因子：
3.4
通讯作者：
Marsh, Derek
中科院分区：
文献类型：
--
作者：
Marsh, Derek
磷脂与胆固醇的混合物能够形成液体有序相，其特征是短程定向有序和远距离平移无序。这些L(o)相不同于液体无序的流体L（α）相和固体有序的凝胶L（β）相，后者是由磷脂单独假设的。液体有序相可以产生空间分离的平面内流体域，以脂筏的形式，被认为是细胞中信号传导和膜分选的平台。在脂质与胆固醇二元混合物的相图中，结构域形成区域由相共存区域定义。本文收集了现有的脂-胆固醇混合物的二元相图。对于同一二元混合物，不同测定方法的相图并不完全一致。这可归因于主要用于建立相界的间接方法。各种数据集的相互比较，可以从相共存的直接证据中严格地确定哪个相边界。(C) 2010 Elsevier B.V.版权所有
Mixtures of phospholipids with cholesterol are able to form liquid-ordered phases that are characterised by short-range orientational order and long-range translational disorder. These L(o)-phases are distinct from the liquid-disordered, fluid L(alpha)-phases and the solid-ordered, gel L(beta)-phases that are assumed by the phospholipids alone. The liquid-ordered phase can produce spatially separated in-plane fluid domains, which, in the form of lipid rafts, are thought to act as platforms for signalling and membrane sorting in cells. The areas of domain formation are defined by the regions of phase coexistence in the phase diagrams for the binary mixtures of lipid with cholesterol. In this paper, the available binary phase diagrams of lipid-cholesterol mixtures are all collected together. It is found that there is not complete agreement between different determinations of the phase diagrams for the same binary mixture. This can be attributed to the indirect methods largely used to establish the phase boundaries. Intercomparison of the various data sets allows critical assessment of which phase boundaries are rigorously established from direct evidence for phase coexistence. (C) 2010 Elsevier B.V. All rights reserved.