Tactile frequency discrimination is enhanced by circumventing neocortical adaptation
Tactile frequency discrimination is enhanced by circumventing neocortical adaptation
复制标题
DOI：
10.1038/nn.3821
复制
发表时间：
2014-11-01
影响因子：
25
通讯作者：
Haiss, Florent
中科院分区：
文献类型：
--
作者：
Musall, Simon;von der Behrens, Wolfger;Haiss, Florent
新皮层反应通常适应重复的感觉刺激，提高对刺激变化的敏感性，但也可能对感知施加限制。例如，目前还不清楚刺激频率的信息是否受到适应的干扰，或者是由精确的反应时间编码的。我们解决了这个问题，在大鼠桶皮层的行为任务与胡须刺激，这会导致频率依赖性的适应，或光学激活的皮质表达的通道视紫红质-2，这elelevens非适应性神经反应的比较性能。通过光学激活来规避适应实质上改善了刺激频率的跨半球辨别。这种改善持续时，光学诱发的尖峰的时间精度降低。我们只能通过应用适应规则模仿对光学刺激的感觉诱发反应来复制胡须驱动的行为。相反，在变化检测任务中，动物用胡须比用光学刺激表现得更好。我们的研究结果直接表明，感官适应至关重要地支配刺激模式的感知，在稳态条件下降低保真度，有利于变化检测。
Neocortical responses typically adapt to repeated sensory stimulation, improving sensitivity to stimulus changes, but possibly also imposing limitations on perception. For example, it is unclear whether information about stimulus frequency is perturbed by adaptation or encoded by precise response timing. We addressed this question in rat barrel cortex by comparing performance in behavioral tasks with either whisker stimulation, which causes frequency-dependent adaptation, or optical activation of cortically expressed channelrhodopsin-2, which elicits non-adapting neural responses. Circumventing adaption by optical activation substantially improved cross-hemispheric discrimination of stimulus frequency. This improvement persisted when temporal precision of optically evoked spikes was reduced. We were able to replicate whisker-driven behavior only by applying adaptation rules mimicking sensory-evoked responses to optical stimuli. Conversely, in a change-detection task, animals performed better with whisker than optical stimulation. Our results directly demonstrate that sensory adaptation critically governs the perception of stimulus patterns, decreasing fidelity under steady-state conditions in favor of change detection.