Predictive Factors of Opioid-Induced Nausea in Cancer Patients
Predictive Factors of Opioid-Induced Nausea in Cancer Patients
复制标题
癌症患者阿片类药物引起恶心的预测因素
DOI：
10.1080/15360288.2020.1829250
复制
发表时间：
2020
影响因子：
1.1
通讯作者：
Y. Kiuchi
中科院分区：
文献类型：
--
作者：
Yasuha Ogawa;T. Kurihara;Mami Sakurai;Megumi Monma;H. Nakayama;Hitomi Higuchi;M. Kogo;Y. Kiuchi
摘要大约30%的患者在阿片类药物治疗开始后会出现恶心，这可能会导致生活质量下降。我们旨在通过对2005年6月至2011年6月期间昭和大学医院病变部位由姑息治疗专家诊断的实体癌症和疼痛患者的医疗记录进行回顾，确定阿片类药物治疗开始时阿片类药物引起恶心的危险因素。主要终点是根据不良事件通用术语标准4.0版在阿片类药物治疗开始后48≥小时内出现恶心程度 1。134名入选患者的中位年龄为67.7岁(28-95岁)。53%的人是男性，44%的人患有胃肠癌。此外，22.4%的人有阿片类药物引起的恶心。年龄(优势比(OR)1.74；95%可信区间(CI)1.13~2.69)、水肿病(OR 5.83；95%CI，1.22~28.19)和胃肠癌(OR 2.61，95%CI 1.07~6.36)与阿片类药物引起的恶心显著相关。预防性止吐药物被发现无效。
Abstract Approximately 30% of patients experience nausea after initiation of opioid therapy, which can lead to poor quality of life. We aimed to identify risk factors for opioid-induced nausea at the initiation of opioid therapy by conducting a retrospective review of medical records of patients diagnosed by palliative care specialists with solid cancer and pain at the lesion site at Showa University Hospital between June 2005 and June 2011. The primary endpoint was the development of nausea grade ≥1 according to the Common Terminology Criteria for Adverse Events version 4.0 within 48 hours of initiation of opioid therapy. The median age of the 134 enrolled patients was 67.7 (range 28–95) years. Fifty-three percent were male and 44% had gastrointestinal cancer. Furthermore, 22.4% had opioid-induced nausea. Age (odds ratio (OR) 1.74; 95% confidence interval (CI), 1.13–2.69), edema (OR 5.83; 95% CI, 1.22–28.19), and gastrointestinal cancer (OR 2.61, 95% CI 1.07–6.36) were significantly associated with opioid-induced nausea. Prophylactic antiemetics were found to be ineffective.
DOI：
10.1073/pnas.95.16.9608
发表时间：
1998-08-04
影响因子：
11.1
作者：
Bond, C;LaForge, KS;Yu, L
通讯作者：
Yu, L