ANGIOGENESIS INHIBITION AND TUMOR-REGRESSION CAUSED BY HEPARIN OR A HEPARIN FRAGMENT IN THE PRESENCE OF CORTISONE
ANGIOGENESIS INHIBITION AND TUMOR-REGRESSION CAUSED BY HEPARIN OR A HEPARIN FRAGMENT IN THE PRESENCE OF CORTISONE
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DOI：
10.1126/science.6192498
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
TAYLOR, S
中科院分区：
文献类型：
--
作者：
FOLKMAN, J;LANGER, R;TAYLOR, S
肝素或肝素片段与可的松一起给药可抑制血管生成，导致大肿瘤块消退，并预防转移。口服肝素导致血清中释放非抗凝肝素片段，在可的松存在下，其具有类似的抗血管生成和抗肿瘤作用。在所有测试的肝素片段中，在可的松存在的情况下，分子量约为 1600 的六糖提供了最有效的血管生成抑制作用。
Heparin or a heparin fragment administered with cortisone inhibited angiogenesis, caused regression of large tumor masses, and prevented metastases. Oral administration of heparin resulted in the release of non-anticoagulant heparin fragments in the serum which, in the presence of cortisone, had similar anti-angiogenic and antitumor effects. Of all the heparin fragments tested, the most potent inhibition of angiogenesis in the presence of cortisone was provided by a hexasaccharide with a molecular weight of about 1600.