Cannabis with high Δ9-THC contents affects perception and visual selective attention acutely: An event-related potential study
Cannabis with high Δ9-THC contents affects perception and visual selective attention acutely: An event-related potential study
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DOI：
10.1016/j.pbb.2010.04.008
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发表时间：
2010-07-01
影响因子：
3.6
通讯作者：
Kenemans, J. L.
中科院分区：
文献类型：
--
作者：
Bocker, K. B. E.;Gerritsen, J.;Kenemans, J. L.
目的：大麻摄入量已被报道会影响认知功能，如选择性注意力。这项研究探讨了暴露于大麻高达69.4毫克三角洲（9）-四氢大麻酚（THC）对事件相关电位（ERP）记录在视觉选择性注意任务的影响。研究方法：在一项随机、双盲、安慰剂对照、交叉研究中，24名参与者在四个测试日吸食大麻香烟和四剂THC。THC暴露后两小时，参与者进行视觉选择性注意任务，并记录伴随的ERP。结果：准确度随THC剂量线性下降，反应时间随THC剂量线性增加。然而，性能指标和大部分的ERP组件，特别是选择性注意没有表现出显着的剂量效应。只有在相对较轻的大麻使用者中，枕骨选择阴性率随剂量线性下降。此外，反映知觉加工的ERP成分，以及P300成分，在THC暴露后的幅度下降。只有前一效应呈线性剂量反应关系。结论：在性能和ERP幅度的递减引起暴露于大麻与高THC含量导致非选择性减少注意力或处理资源。重要性：需要注意力资源的表现，如车辆控制，可能会在吸食含有高剂量四氢大麻酚的大麻香烟后几个小时受到损害，如目前在欧洲和北方美洲。(C)2010爱思唯尔公司All rights reserved.
Objective: Cannabis intake has been reported to affect cognitive functions such as selective attention. This study addressed the effects of exposure to cannabis with up to 69.4 mg Delta(9)-tetrahydrocannabinol (THC) on Event-Related Potentials (ERPs) recorded during a visual selective attention task. Methods: Twenty-four participants smoked cannabis cigarettes with four doses of THC on four test days in a randomized, double blind, placebo-controlled, crossover study. Two hours after THC exposure the participants performed a visual selective attention task and concomitant ERPs were recorded. Results: Accuracy decreased linearly and reaction times increased linearly with THC dose. However, performance measures and most of the ERP components related specifically to selective attention did not show significant dose effects. Only in relatively light cannabis users the Occipital Selection Negativity decreased linearly with dose. Furthermore, ERP components reflecting perceptual processing, as well as the P300 component, decreased in amplitude after THC exposure. Only the former effect showed a linear dose-response relation. Conclusions: The decrements in performance and ERP amplitudes induced by exposure to cannabis with high THC content resulted from a non-selective decrease in attentional or processing resources. Significance: Performance requiring attentional resources, such as vehicle control, may be compromised several hours after smoking cannabis cigarettes containing high doses of THC, as presently available in Europe and Northern America. (C) 2010 Elsevier Inc. All rights reserved.