Epigenetic pre-patterning and dynamics during initial stages of mammalian preimplantation development.
Epigenetic pre-patterning and dynamics during initial stages of mammalian preimplantation development.
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哺乳动物植入前发育初始阶段的表观遗传预模式和动态。
DOI：
10.1002/jcp.22293
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发表时间：
2010
影响因子：
5.6
通讯作者：
Corry,GarethN
中科院分区：
文献类型：
--
作者：
Rasmussen,TheodoreP;Corry,GarethN
哺乳动物，像所有的多细胞生物一样，是从一个单细胞——全能的受精卵发育而来的。在胚胎着床前发育和随后的子宫发育过程中，超过200种不同类型的细胞被建立并整合到发育中的生物体的器官系统和组织中。哺乳动物发育生物学的大部分领域都致力于研究控制完整器官和组织形成的机制。与后期发育相比，后期发育消耗了子宫内发育的绝大部分时间，而着床前发育和胚层发育发生得很快。然而，关于哺乳动物发育初期形成的短暂但多能的细胞谱系的调控机制的知识有限。配子发生和着床前发育的特点是显著和普遍的表观遗传变化植根于染色质动力学。指定概念的后续细胞谱系的基本机制现在才开始被理解，并且倾向于相对严重地依赖于除了主转录因子之外的广泛的表观遗传机制。本文综述了胚胎着床前发育的早期阶段的表观遗传调控。此外，最近的研究进展表明，一些表观遗传编码在配子体发生过程中被施加并在着床前发育过程中维持。j .细胞。中国生物医学工程学报，2009,31(2):393 - 396。©2010 Wiley‐Liss, Inc。
Mammals, like all multicellular organisms, develop from a single cell—the totipotent zygote. During preimplantation development and subsequent development in utero, over 200 distinct cell types are established and integrated into the organ systems and tissues of the developing organism. Much of the field of mammalian developmental biology is devoted to investigation of mechanisms that govern the formation of complete organs and tissues. In contrast to later development, which consumes the vast majority of time associated with development in utero, preimplantation development and germ layer specification occur rapidly. Yet knowledge is limited regarding the regulatory mechanisms that specify the transient, but pluripotent, cellular lineages that form during the initial stages of mammalian development. Gametogenesis and preimplantation development are marked by dramatic and pervasive epigenetic changes rooted in chromatin dynamics. The fundamental mechanisms that specify subsequent cellular lineages of the conceptus are only now becoming understood, and tend to rely relatively heavily upon broad epigenetic mechanisms in addition to master transcription factors. This review considers epigenetic regulation in the very earliest stages of preimplantation development. In addition, recent advances which indicate that some epigenetic coding is imposed during gametogenesis and maintained during preimplantation development are considered. J. Cell. Physiol. 225: 333–336, 2010. © 2010 Wiley‐Liss, Inc.