Effects of Habitual Cigarette Smoking on Retinal Circulation in Patients With Type 2 Diabetes
Effects of Habitual Cigarette Smoking on Retinal Circulation in Patients With Type 2 Diabetes
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DOI：
10.1167/iovs.15-18813
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发表时间：
2016-03-01
影响因子：
4.4
通讯作者：
Yoshida, Akitoshi
中科院分区：
文献类型：
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作者：
Omae, Tsuneaki;Nagaoka, Taiji;Yoshida, Akitoshi
目的。目的探讨吸烟对2型糖尿病患者视网膜循环的长期影响。方法：对74例2型糖尿病伴轻度(无或轻度非增殖性)糖尿病视网膜病变(DR)患者进行研究。根据吸烟史将2型糖尿病患者分为三组：现吸烟者(n=19)、既往吸烟者(n=20)和从不吸烟者(n=35)。结果治疗后视网膜血流量显著降低(P=0.009)，血流速度明显降低(P=0.003)，血管直径无明显变化(D；P=0.003)。112.0+/-11.9vs 113.7+/-8.6万亩，P=0.57)。既往吸烟者与不吸烟者及现吸烟者相比，RBF、血V、血管D均无明显差异。多元回归分析显示，血肌酐水平与RBF呈显著负相关，吸烟与RBF下降呈显著正相关。结论提示2型糖尿病患者长期吸烟可导致视网膜小动脉血V、RBF降低，提示慢性吸烟可能与早期DR患者视网膜小动脉血V降低有关。
PURPOSE. To examine the long-term effects of cigarette smoking on retinal circulation in patients with type 2 diabetes.METHODS. Seventy-four patients with type 2 diabetes mellitus and minimal (no or mild nonproliferative) diabetic retinopathy (DR) were evaluated. These patients with type 2 diabetes were divided into three groups based on their smoking history: current smokers (n = 19), past smokers (n = 20), and never smoked (n = 35). The retinal circulatory parameters were measured with laser Doppler velocimetry and were compared among the groups.RESULTS. There were significant decreases in the retinal blood flow (RBF; 8.9 +/- 2.9 vs. 11.6 +/- 3.1 mu L/min, P = 0.009) with decreased blood velocity (V; 29.6 +/- 6.8 vs. 37.8 +/- 9.0 mm/s, P = 0.003) but no difference in the vessel diameter (D; 112.0 +/- 11.9 vs. 113.7 +/- 8.6 mu m, P = 0.57) in the current smokers compared with those who never smoked. There were no differences in the RBF, blood V, and vessel D in the past smokers compared with those who never smoked and current smokers. Multiple regression analysis showed that the creatinine level was correlated negatively with the RBF and that current smoking was significantly and independent correlated with decreased RBF.CONCLUSIONS. Our results indicated that the blood V and RBF in the retinal arterioles may decrease in patients with type 2 diabetes who are chronic smokers, suggesting that chronic smoking may be associated with decreased RBF, probably via lower blood V in the retinal arterioles in early-phase DR.