International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: The NMSQuest study
International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: The NMSQuest study
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DOI：
10.1002/mds.20844
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发表时间：
2006-07-01
影响因子：
8.6
通讯作者：
Olanow, Charles W.
中科院分区：
文献类型：
--
作者：
Chaudhuri, Kallol Ray;Martinez-Martin, Pablo;Olanow, Charles W.
帕金森病（PD）的非运动症状（NMS）在临床实践中没有得到很好的认识，无论是在初级还是二级护理中，并且在常规咨询中经常被遗漏。没有一种单一的工具（问卷或量表）能够全面评估PD中NMS的范围，以识别问题和测量结果。在此背景下，一个多学科专家组，包括患者群体代表，制定了一个包括30个项目的NMS筛查问卷。该工具不提供残疾的总体评分，也不是分级或评级工具。相反，它是一种筛选工具，旨在引起人们对NMS存在的注意，并启动进一步调查。在这篇文章中，我们提出了一个国际试点研究评估的可行性，有效性和可接受的非运动问卷（NMSQuest）的结果。分析了123例PD患者和96例对照的数据。与对照组相比，NMS在PD中非常显著地更普遍（PD，NMS，中位数= 9.0，平均值= 9.5 vs.对照NMS，中位数= 5.5，平均值= 4.0; Mann-Whitney，Kruskal-Wallis和t检验，P < 0.0001），PD患者平均每例患者报告至少10种不同的NMS。在PD中，NMS在所有疾病阶段的患病率都非常显著，症状数量与疾病进展和疾病持续时间显著相关。此外，通常情况下，复视、流口水、冷漠、忧郁、味觉和嗅觉问题等问题以前从未向卫生专业人员披露。(C)2006年，《社会运动》创刊。
Nonmotor symptoms (NMS) of Parkinson's disease (PD) are not well recognized in clinical practice, either in primary or in secondary care, and are frequently missed during routine consultations. There is no single instrument (questionnaire or scale) that enables a comprehensive assessment of the range of NMS in PD both for the identification of problems and for the measurement of outcome. Against this background, a multidisciplinary group of experts, including patient group representatives, has developed an NMS screening questionnaire comprising 30 items. This instrument does not provide an overall score of disability and is not a graded or rating instrument. Instead, it is a screening tool designed to draw attention to the presence of NMS and initiate further investigation. In this article, we present the results from an international pilot study assessing feasibility, validity, and acceptability of a nonmotor questionnaire (NMSQuest). Data from 123 PD patients and 96 controls were analyzed. NMS were highly significantly more prevalent in PD compared to controls (PD, NMS, median = 9.0, mean = 9.5 vs. control NMS, median = 5.5, mean = 4.0; Mann-Whitney, Kruskal-Wallis, and t test, P < 0.0001), with PD patients reporting at least 10 different NMS on average per patient. In PD, NMS were highly significantly more prevalent across all disease stages and the number of symptoms correlated significantly with advancing disease and duration of disease. Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals. (C) 2006 Movement Disorder Society.