Intracellular α(2C)-adrenoceptors: storage depot, stunted development or signaling domain?
Intracellular α(2C)-adrenoceptors: storage depot, stunted development or signaling domain?
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DOI：
10.1016/j.bbamcr.2011.05.006
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Flavahan NA
中科院分区：
文献类型：
--
作者：
Chotani MA;Flavahan NA
G-protein coupled receptors (GPCRs) are generally considered to function as cell surface signaling structures that respond to extracellular mediators, many of which do not readily access the cell’s interior. Indeed, most GPCRs are preferentially targeted to the plasma membrane. However, some receptors, including α2C-adrenoceptors, challenge conventional concepts of GPCR activity by being preferentially retained and localized within intracellular organelles. This review will address the issues associated with this unusual GPCR localization and discuss whether it represents a novel sub-cellular niche for GPCR signaling, whether these receptors are being stored for rapid deployment to the cell surface, or whether they represent immature or incomplete receptor systems.
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DOI：
10.1111/j.1600-0854.2010.01033.x
发表时间：
2010-04
期刊：
Traffic (Copenhagen, Denmark)
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