Clinical Monitoring of Smooth Surface Enamel Lesions Using CP-OCT During Nonsurgical Intervention
Clinical Monitoring of Smooth Surface Enamel Lesions Using CP-OCT During Nonsurgical Intervention
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DOI：
10.1002/lsm.22500
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发表时间：
2016-12-01
影响因子：
2.4
通讯作者：
Fried, Daniel
中科院分区：
文献类型：
--
作者：
Chan, Kenneth H.;Tom, Henry;Fried, Daniel
前言：研究表明，交叉偏振光学相干层析成像(CP-OCT)可用于活体成像龋病病变的内部结构。本研究的目的是证明CP-OCT可用于监测氟化物非手术干预期间光滑表面早期活动性龋损的内部结构变化。方法：对17名受试者进行CP-OCT扫描。在使用氟化物涂料期间，每隔6周监测病变结构的变化，持续30周。结果：涂氟前62/63个病灶在CP-OCT图像上可见明显的透明表面区，提示病变被阻挡。所有病变的病变深度和内部结构都得到了解决。所有病变的L-d、Delta R和S-z的平均值的总体变化很小，在研究期间没有显著意义(P>；0.05)。仅有5/63个病灶在介入治疗期间S-z水平明显升高。结论：尽管在研究的30周内，大多数病灶在涂氟清漆后变化不大，但CP-OCT能够测量所有病变的深度和内部结构，包括位于病变表面的重要透明表面区的厚度，表明CP-OCT是一种理想的在体监测病变严重程度的方法。(C)2016威利期刊公司。
Introduction: Studies have shown that cross-polarization optical coherence tomography (CP-OCT) can be used to image the internal structure of carious lesions in vivo. The objective of this study was to show that CP-OCT can be used to monitor changes in the internal structure of early active carious lesions on smooth surfaces during nonsurgical intervention with fluoride.Methods: Lesions on the smooth surfaces of teeth were imaged using CP-OCT on 17 test subjects. Lesion structural changes were monitored during fluoride varnish application at 6-week intervals for 30 weeks. The lesion depth (L-d), integrated reflectivity (Delta R), and surface zone thickness (S-z) were monitored.Results: A distinct transparent surface zone that may be indicative of lesion arrestment was visible in CP-OCT images on 62/63 lesions before application of fluoride varnish. The lesion depth and internal structure were resolved for all the lesions. The overall change in the mean values for L-d, Delta R, and S-z for all the lesions was minimal and was not significant during the study (P>0.05). Only 5/63 lesions manifested a significant increase in S-z during intervention.Conclusion: Even though it appears that most of the lesions manifested little change with fluoride varnish application in the 30 weeks of the study, CP-OCT was able to measure the depth and internal structure of all the lesions including the thickness of the important transparent surface zone located at the surface of the lesions, indicating that CP-OCT is ideally suited for monitoring lesion severity in vivo. (C) 2016 Wiley Periodicals, Inc.