Starting a new chapter on class Ia ribonucleotide reductases.
Starting a new chapter on class Ia ribonucleotide reductases.
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DOI：
10.1016/j.sbi.2022.102489
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发表时间：
2022-10
影响因子：
6.8
通讯作者：
T. Levitz;C. Drennan
中科院分区：
文献类型：
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作者：
T. Levitz;C. Drennan
核糖核苷酸还原酶（RNR）使用基于自由基的化学将核糖核苷酸转化为脱氧核糖核苷酸，这是DNA生物合成和修复的重要步骤。有多个RNR类别，其中研究最多的是在大肠杆菌、真核生物（包括人类）和许多致病性和非致病性原核生物中发现的Ia类RNR。这篇综述涵盖了我们对Ia类RNR理解的最新进展，包括最近报道的大肠杆菌酶活性状态的结构以及该结构对促进远程自由基转移机制研究的影响。此外，审查考虑了其他最近的结构和生化研究Ia类RNR和抗癌和抗生素治疗的发展工作的潜力。
Ribonucleotide reductases (RNRs) use radical-based chemistry to convert ribonucleotides into deoxyribonucleotides, an essential step in DNA biosynthesis and repair. There are multiple RNR classes, the best studied of which is the class Ia RNR that is found inEscherichia coli, eukaryotes including humans, and many pathogenic and nonpathogenic prokaryotes. This review covers recent advances in our understanding of class Ia RNRs, including a recent reporting of a structure of the active state of theE. colienzyme and the impacts that the structure has had on spurring research into the mechanism of long-range radical transfer. Additionally, the review considers other recent structural and biochemical research on class Ia RNRs and the potential of that work for the development of anticancer and antibiotic therapeutics.