Implementation determinants and mechanisms for the prevention and treatment of adolescent HIV in sub-Saharan Africa: concept mapping of the NIH Fogarty International Center Adolescent HIV Implementation Science Alliance (AHISA) initiative.

Implementation determinants and mechanisms for the prevention and treatment of adolescent HIV in sub-Saharan Africa: concept mapping of the NIH Fogarty International Center Adolescent HIV Implementation Science Alliance (AHISA) initiative.
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DOI:
10.1186/s43058-021-00156-3
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发表时间:
2021-05-22
影响因子:
--
通讯作者:
Sturke R
Sturke R
中科院分区:
其他
文献类型:
--
作者:
Aarons GA;Reeder K;Sam-Agudu NA;Vorkoper S;Sturke R

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青少年艾滋病毒预防和治疗是撒哈拉以南非洲地区青年医疗保健的重中之重。本研究采用概念图来确定影响撒哈拉以南非洲青少年艾滋病毒预防和干预计划实施的因素。主要利益相关者,包括研究人员、政策制定者和非政府组织 (NGO) 人员,这些人员是 NIH 资助的青少年艾滋病毒预防和治疗实施科学联盟的成员,他们回答了以下问题:“根据您的经验,哪些因素促进或阻碍了对撒哈拉以南非洲青少年实施基于证据的艾滋病毒预防或治疗?”参与者针对焦点问题生成陈述,将其分类到主题相关的组中,并对每个陈述的重要性和可变性进行评级。通过数据分析和参与者反馈,得出了 15 个不同的主题。 “劳动力/工作流程”和“艾滋病毒耻辱和青少年发展”的重要性被评为最高,“治疗的阈值条件”和“实施工作的结构”被评为变化最大的。了解实施科学决定因素和机制可以促进在特定背景下成功实施和维持艾滋病毒预防和治疗战略。我们将决定因素和机制置于探索、准备、实施、维持 (EPIS) 框架内,以提供与实施科学中更广泛理论的更大背景整合。多个学科的实施者可以利用这些发现来扩大撒哈拉以南非洲青少年艾滋病毒预防和治疗的循证实践。考虑本研究中确定的决定因素和机制并纳入实施框架的实施方法可能对其他健康状况和背景有用。在线版本包含可在 10.1186/s43058-021-00156-3 获取的补充材料。
Adolescent HIV prevention and treatment is a high priority for youth healthcare in sub-Saharan Africa. This study employed concept mapping to identify factors that impact the implementation of HIV prevention and intervention programs for adolescents in sub-Saharan Africa. Key stakeholders including researchers, policymakers, and non-governmental organization (NGO) personnel constituting membership of the NIH-sponsored Adolescent HIV Prevention and Treatment Implementation Science Alliance responded to the question: “In your experience, what factors have facilitated or hindered implementation of evidence-based HIV prevention or treatment for adolescents in sub-Saharan Africa?” Participants generated statements in response to the focus question, sorted them into thematically relevant groups, and rated each statement on its importance and changeability. Through data analyses and participant feedback, 15 distinct themes were derived. “Workforce/Workflow” and “HIV Stigma and Adolescent Development” were rated highest for importance, and “Threshold Conditions for Treatment” and “Structure of Implementation Efforts” were rated most changeable. Understanding implementation science determinants and mechanisms can facilitate the uptake of successful implementation and sustainment strategies for the prevention and treatment of HIV in a given context. We placed determinants and mechanisms within the Exploration, Preparation, Implementation, Sustainment (EPIS) framework to provide greater contextual integration with broader theories in implementation science. Implementers across multiple disciplines can use these findings to improve the scale-up of evidence-based practices for adolescent HIV prevention and treatment in sub-Saharan Africa. Implementation approaches that consider the determinants and mechanisms identified in this study and integrated in implementation frameworks will likely have utility for other health conditions and contexts. The online version contains supplementary material available at 10.1186/s43058-021-00156-3.
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