The role of epidemiology in the era of molecular epidemiology and genomics: Summary of the 2013 AJE-sponsored Society of Epidemiologic Research Symposium.
The role of epidemiology in the era of molecular epidemiology and genomics: Summary of the 2013 AJE-sponsored Society of Epidemiologic Research Symposium.
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DOI：
10.1093/aje/kwt239
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发表时间：
2013-11
影响因子：
5
通讯作者：
L. Kuller;M. Bracken;S. Ogino;R. Prentice;R. Tracy
中科院分区：
文献类型：
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作者：
L. Kuller;M. Bracken;S. Ogino;R. Prentice;R. Tracy
2013年6月20日，《美国流行病学杂志》在马萨诸塞州波士顿举行的流行病学研究学会第46届年会上主办了一场研讨会，题为“流行病学在分子生物学和基因组学时代的作用是什么？”流行病学的未来取决于产生与人口健康相关的有趣且重要的可检验假设的创新。这些新策略将依赖于新技术，无论是在媒介和环境的测量方面，还是在病理生理学和结果领域，例如细胞流行病学和分子病理学。应根据要测试的假设来选择要研究的人群、样本量和研究设计，包括病例对照、队列和临床试验。在不关注具体假设的情况下开发大型队列是低效的，将无法解决与高质量数据的许多关联，并且很可能产生虚假结果。
On June 20, 2013, the American Journal of Epidemiology sponsored a symposium at the Society for Epidemiologic Research's 46th Annual Meeting in Boston, Massachusetts, entitled, "What Is the Role of Epidemiology in the Era of Molecular Biology and Genomics?" The future of epidemiology depends on innovation in generating interesting and important testable hypotheses that are relevant to population health. These new strategies will depend on new technology, both in measurement of agents and environment and in the fields of pathophysiology and outcomes, such as cellular epidemiology and molecular pathology. The populations to be studied, sample sizes, and study designs should be selected based on the hypotheses to be tested and include case-control, cohort, and clinical trials. Developing large mega cohorts without attention to specific hypotheses is inefficient, will fail to address many associations with high-quality data, and may well produce spurious results.