Genetics of Bipolar Disorder: Recent Update and Future Directions.
Genetics of Bipolar Disorder: Recent Update and Future Directions.
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DOI：
10.1016/j.psc.2015.10.004
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Goes FS
中科院分区：
文献类型：
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作者：
Goes FS
可以肯定地说，与双相情感障碍（BD）相关的遗传因素研究已经进入成熟阶段，具备了相应的能力，开始为双相情感障碍的病理生理学提供期待已久的见解。大规模微阵列基因分型和下一代测序等技术创新使这些进展成为可能，这些技术已以全基因组综合的方式应用于大样本。现在已经有几个基因与双相情感障碍有很强的关联性，预计2016年精神病基因组学联盟（PGC）的分析将产生更多类似的发现。这些努力的初步成果将是确定分子靶点和通路，从而深入了解双相情感障碍的潜在生物学机制，进而促进新药研发。最终，随着该领域的进展以及更多的遗传因素被解释，诸如风险分层和基于生物学信息的药物选择等更直接的临床应用也可能变得可行。然而，为了跟上技术进步的步伐，现在迫切需要临床医疗与研究“合作”，提供实现精准医学承诺所需的样本量和相关表型。
The study of genetic factors associated with BD can be safely said to have entered a mature phase, with the appropriate capacity to begin to provide the long awaited insights into the pathophysiology of BD. These advances have been made possible by technological innovations such as large-scale microarray genotyping and next generation sequencing, which have been applied in a comprehensive genome-wide manner to large samples. Several genes have now been robustly associated with BD and in 2016 analyses by the PGC are expected to yield many more similar findings. The initial fruits of such efforts will be to identify molecular targets and pathways that provide insights into the underlying biology of BD and thereby facilitate novel drug development. Eventually, as the field progresses and a greater proportion of heritability is accounted for, more immediate clinical applications such as risk stratification and biologically informed drug selection may also become feasible. However, to keep pace with the technological advances, there is a pressing need now for clinical care to “partner” with research and provide both the samples sizes and the relevant phenotypes necessary to fulfill the promise of precision medicine.
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来自1,092个人基因组的遗传变异的综合图。
影响因子：
64.8
作者：
通讯作者：
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DOI：
10.1126/science.aaa3650
发表时间：
2015-03-27
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Cirulli ET;Lasseigne BN;Petrovski S;Sapp PC;Dion PA;Leblond CS;Couthouis J;Lu YF;Wang Q;Krueger BJ;Ren Z;Keebler J;Han Y;Levy SE;Boone BE;Wimbish JR;Waite LL;Jones AL;Carulli JP;Day-Williams AG;Staropoli JF;Xin WW;Chesi A;Raphael AR;McKenna-Yasek D;Cady J;Vianney de Jong JM;Kenna KP;Smith BN;Topp S;Miller J;Gkazi A;FALS Sequencing Consortium;Al-Chalabi A;van den Berg LH;Veldink J;Silani V;Ticozzi N;Shaw CE;Baloh RH;Appel S;Simpson E;Lagier-Tourenne C;Pulst SM;Gibson S;Trojanowski JQ;Elman L;McCluskey L;Grossman M;Shneider NA;Chung WK;Ravits JM;Glass JD;Sims KB;Van Deerlin VM;Maniatis T;Hayes SD;Ordureau A;Swarup S;Landers J;Baas F;Allen AS;Bedlack RS;Harper JW;Gitler AD;Rouleau GA;Brown R;Harms MB;Cooper GM;Harris T;Myers RM;Goldstein DB
通讯作者：
Goldstein DB
影响因子：
11
作者：
Brennand, K. J.;Simone, A.;Tran, N.;Gage, F. H.
通讯作者：
Gage, F. H.
影响因子：
6.8
作者：
Chen HM;DeLong CJ;Bame M;Rajapakse I;Herron TJ;McInnis MG;O'Shea KS
通讯作者：
O'Shea KS
影响因子：
9.8
作者：
Cichon, Sven;Muehleisen, Thomas W.;Noethen, Markus M.
通讯作者：
Noethen, Markus M.