Optimal Implementations for Reliable Circadian Clocks
Optimal Implementations for Reliable Circadian Clocks
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DOI：
10.1103/physrevlett.113.108101
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发表时间：
2014-09-04
影响因子：
8.6
通讯作者：
Arita, Masanori
中科院分区：
文献类型：
--
作者：
Hasegawa, Yoshihiko;Arita, Masanori
昼夜节律是通过进化获得的，通过与日光周期同步来增加生存的机会。可靠的同步是通过两个权衡属性来实现的：精确保持时间的规律性，以及将内部时间与日光同步的夹带性。我们发现，通过使用具有多个输入的相位模型，实现规律性和可重复性的最大限度需要昼夜节律机制的许多固有特征。在分子水平上，我们证明了两个光输入，相位提前和延迟，以及在哺乳动物中观察到的作用共享。在行为层面，最佳相位响应曲线不可避免地包含一个死区，在此期间，光脉冲既不提前也不延迟时钟。我们再现了两种类型的周期性光脉冲夹带的相位控制实验的结果。我们的研究结果表明，生物钟是经过进化而设计的最佳可靠时钟。
Circadian rhythms are acquired through evolution to increase the chances for survival through synchronizing with the daylight cycle. Reliable synchronization is realized through two trade-off properties: regularity to keep time precisely, and entrainability to synchronize the internal time with daylight. We find by using a phase model with multiple inputs that achieving the maximal limit of regularity and entrainability entails many inherent features of the circadian mechanism. At the molecular level, we demonstrate the role sharing of two light inputs, phase advance and delay, as is well observed in mammals. At the behavioral level, the optimal phase-response curve inevitably contains a dead zone, a time during which light pulses neither advance nor delay the clock. We reproduce the results of phase-controlling experiments entrained by two types of periodic light pulses. Our results indicate that circadian clocks are designed optimally for reliable clockwork through evolution.