Attentional control of task and response in lateral and medial frontal cortex: Brain activity and reaction time distributions
Attentional control of task and response in lateral and medial frontal cortex: Brain activity and reaction time distributions
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DOI：
10.1016/j.neuropsychologia.2009.03.019
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发表时间：
2009-08-01
期刊：
影响因子：
2.6
通讯作者：
van Turennout, Miranda
中科院分区：
文献类型：
--
作者：
Aarts, Esther;Roelofs, Ardi;van Turennout, Miranda
目前还不清楚任务冲突是否反映在前扣带皮层（ACC）或内侧额叶皮层（MFC）的背侧区域。当参与者在涉及不一致，一致和中性刺激的任务之间切换时，可以检查反应冲突（不一致vs.一致）和任务冲突（一致vs.中性）。在这里，我们报告了一个事件相关的功能磁共振成像（fMRI）研究，探讨在额叶皮层，包括MFC，有牵连的反应冲突，任务冲突，或两者兼而有之。刺激是不一致和一致的箭头词组合，或箭头和词只在中性条件。参与者手动响应箭头或单词。每两次试验的任务都不同。行为学数据在平均反应时和前高斯潜伏期分布中表现出反应冲突（不一致>一致）和任务冲突（一致>中性）。成像数据显示，前扣带回和MFC（内侧上级额回）的背侧区域的活动与反应冲突以及任务冲突有关。观察到这些冲突的影响独立的任务进行（箭头或单词）或试验类型（重复或开关）。在外侧前额叶皮层（LPFC），反应冲突与腹侧LPFC的活动，而任务冲突激活腹侧和背侧区域。因此，而类型的冲突（响应与任务）区分在LPFC，没有这样的分化被发现在MFC，包括ACC。模型的ACC功能可能需要修改，以考虑到这些发现。(C)2009爱思唯尔有限公司保留所有权利。
It is unclear whether task conflict is reflected in the anterior cingulate cortex (ACC) or in more dorsal regions of the medial frontal cortex (MFC). When participants switch between tasks involving incongruent, congruent, and neutral stimuli, it is possible to examine both response conflict (incongruent vs. congruent) and task conflict (congruent vs. neutral). Here, we report an event-related functional magnetic resonance imaging (fMRI) study that examined which areas in frontal cortex, including MFC, are implicated in response conflict, task conflict, or both. Stimuli were incongruent and congruent arrow-word combinations, or arrows and words only in a neutral condition. Participants responded manually to the arrow or word. The task varied every second trial. The behavioral data revealed response conflict (incongruent > congruent) and task conflict (congruent > neutral) in mean reaction times and ex-Gaussian latency distribution components. The imaging data revealed activity in both the ACC and a more dorsal region in the MFC (the medial superior frontal gyrus) related to response conflict as well as task conflict. These conflict effects were observed independent of the task performed (arrow or word) or the trial type (repeat or switch). In lateral prefrontal cortex (LPFC), response conflict was associated with activity in ventral LPFC, whereas task conflict activated both ventral and dorsal regions. Thus, whereas the type of conflict (response vs. task) was differentiated in LPFC, no such differentiation was found in MFC, including the ACC. Models of ACC functioning may require modification to take account of these findings. (C) 2009 Elsevier Ltd. All rights reserved.