The polyphenol chlorogenic acid inhibits staphylococcal exotoxin-induced inflammatory cytokines and chemokines
The polyphenol chlorogenic acid inhibits staphylococcal exotoxin-induced inflammatory cytokines and chemokines
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DOI：
10.1081/iph-120003407
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发表时间：
2002-01-01
影响因子：
3.3
通讯作者：
Krakauer, T
中科院分区：
文献类型：
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作者：
Krakauer, T
促炎症细胞因子介导葡萄球菌外毒素(SE)的毒性作用。绿原酸是一种植物多酚，可抑制SE诱导的T细胞增殖(达98%)，抑制人外周血单核细胞产生IL-1β、肿瘤坏死因子、IL-6、干扰素-γ、单核细胞趋化蛋白-1(MCP-1)、巨噬细胞炎性蛋白-1α(MIP-1α)和MIP-1β。这些数据表明，绿原酸可能在治疗上有助于减轻SE的致病效应。天然产生的多酚化合物，如绿原酸，可作为传统化疗药物的有效抗炎剂替代品。
Proinflammatory cytokines mediate the toxic effect of staphylococcal exotoxins (SE). Chlorogenic acid, a plant polyphenol, inhibited SE-induced T-cell proliferation (by 98%) and production of interleukin 1beta, tumor necrosis factor, interleukin 6, interferon gamma, monocyte chemotactic protein 1 (MCP-1), macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta by human peripheral blood mononuclear cells. These data indicate that chlorogenic acid may be therapeutically useful for mitigating the pathogenic effects of SE. Naturally occurring polyphenolic compounds such as chlorogenic acid may serve as a potent anti-inflammatory agent alternative to conventional chemotherapeutics.