Synthesis of glycopeptoid sulfonamides diversifying N-glycopeptide linkage region mimics
Synthesis of glycopeptoid sulfonamides diversifying N-glycopeptide linkage region mimics
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DOI：
10.1039/c4ra01009d
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发表时间：
2014-01-01
期刊：
影响因子：
3.9
通讯作者：
Loganathan, Duraikkannu
中科院分区：
文献类型：
--
作者：
Singhamahapatra, Anadi;Sahoo, Laxminarayan;Loganathan, Duraikkannu
用糖肽骨架上的四面体磺胺取代平面羧胺类化合物，以不同功能基团的β-酰胺或β-磺胺连接氨基酸为原料，合成了具有不同结构的N-糖肽模拟物。磺胺基团以不同的构象存在，参与C-H…O相互作用。
Replacing the planar carboxamides with tetrahedral sulfonamides in the glycopeptoid backbone, glycopeptoid sulfonamides were synthesized as N-glycopeptide mimicswith diverse structures using bpeptoid, chiral amino acids and beta-amide or beta-sulfonamide linked amino acids with different functional groups. The sulfonamide group exists in different conformations and participates in C-H...O interactions.