Pharmacokinetic drug interactions between opioid agonist therapy and antiretroviral medications: Implications and management for clinical practice
Pharmacokinetic drug interactions between opioid agonist therapy and antiretroviral medications: Implications and management for clinical practice
复制标题
DOI：
10.1097/01.qai.0000219769.89679.ec
复制
发表时间：
2006-04-15
影响因子：
3.6
通讯作者：
Friedland, GH
中科院分区：
文献类型：
--
作者：
Bruce, RD;Altice, FL;Friedland, GH
背景：阿片类药物依赖和艾滋病毒/艾滋病是全球最严重但可治疗的两种疾病。全球范围内获得阿片类激动剂治疗和艾滋病毒治疗正在扩大，但同时使用时，有问题的药代动力学药物相互作用可能occurs.Methods：我们回顾了英语，西班牙语，法语和意大利语的文章，从1966年至2005年在Medline使用以下关键词：艾滋病毒，艾滋病，艾滋病毒治疗，抗逆转录病毒治疗，HAART，药物相互作用，美沙酮，丁丙诺啡。此外，我们回顾了国内和国际会议的摘要和会议记录。这些文章前面选定的参考文献进行了reviewed.Results：临床病例系列和仔细控制的药物动力学相互作用研究美沙酮和大多数批准的抗逆转录病毒疗法之间进行。重要的plarmacokinetic药物相互作用已被证明在每一类药物，影响美沙酮或抗逆转录病毒药物。然而，很少有研究与丁丙诺啡进行。这两种疗法的代谢，描述已知的相互作用，和临床意义和管理这些interactions.Conclusions：美沙酮和抗逆转录病毒药物之间的某些相互作用是已知的，可能有重要的临床后果。为了优化护理，临床医生必须对这些相互作用保持警惕，并对其管理有基本的了解。
Background: Opioid dependence and HIV/AIDS are 2 of the most serious yet treatable diseases worldwide. Global access to opioid agonist therapy and HIV treatment is expanding but when concurrently used, problematic pharmacokinetic drug interactions can occur.Methods: We reviewed English, Spanish, French, and Italian language articles from 1966 to 2005 in Medline using the following keywords: HIV, AIDS, HIV therapy, antiretroviral therapy, HAART, drug interactions, methadone, and buprenorphine. Additionally, we reviewed abstracts from national and international meetings and conference proceedings. Selected references front these articles were reviewed as well.Results: Clinical case series and carefully controlled pharmacokinetic interaction studies have been conducted between methadone and most approved antiretroviral therapies. Important plarmacokinetic drug interactions have been demonstrated within each class of agents, affecting either methadone or antiretroviral agents. Few studies, however, have been conducted with buprenorphine. The metabolism of both therapies, description of the known interactions, and clinical implications and management of these interactions are reviewed.Conclusions: Certain interactions between methadone and antiretroviral medications are known and may have important clinical consequences. To optimize care, clinicians Must be alert to these interactions and have a basic knowledge regarding their management.