In vitro evaluation of an asthma dosing device: The smart-inhaler
In vitro evaluation of an asthma dosing device: The smart-inhaler
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DOI：
10.1016/j.rmed.2005.09.004
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发表时间：
2006-05-01
影响因子：
4.3
通讯作者：
Devadason, SG
中科院分区：
文献类型：
--
作者：
Burgess, SW;Wilson, SSI;Devadason, SG
在临床和研究环境中，连接到加压定量吸入器的监测装置提供了患者对哮喘药物依从性的重要客观测量。智能吸入器是一种相对较新的设备，以前尚未经过验证。本研究在实验室实验中检查了智能吸入器的准确性，并将其与先前验证的设备Doser进行了比较。10个智能吸入器和5个剂量器每天启动两次，持续30天（120剂）。六个智能吸入器也被快速连续启动30次，以检查智能吸入器检测“倾倒”的能力。五个智能吸入器未能检测到前一两次剂量。然而，当气雾剂罐更牢固地放置在装置中时，在该过程中启动装置，在所有10个装置中准确记录了以下两个剂量。否则，所有10个智能吸入器和5个剂量器都如实记录了所有揿数，没有虚假记录。六个智能吸入器记录了快速连续输送的所有30个剂量。智能吸入器和给药器在测量驱动剂量时都非常准确，并且在体外设置中没有记录虚假剂量。(c)2005爱思唯尔有限公司保留所有权利。
Monitoring devices attached to pressurised metered dose inhalers provide an important objective measurement of patient adherence with asthma medications in clinical and research settings. The Smart-inhaler is a relatively new device that has not been previously validated. This study examines the accuracy of the Smart-inhaler in a bench-top experiment and compares it with a previously validated device, the Doser. Ten Smart-inhalers and five Dosers were actuated twice on two occasions per day for 30 days (120 doses). Six Smart-inhalers were also actuated 30 times in rapid succession to examine the ability of the Smart-inhaler to detect "dumping". Five Smart-inhalers failed to detect the first one or two doses. However, when the aerosol canister was placed more firmly in the device, actuating the device in the process, the following two doses were recorded accurately in all ten devices. Otherwise all ten Smart-inhalers and five Dosers recorded all actuations faithfully and there were no spurious recordings. The six Smart-inhalers recorded all 30 doses delivered in rapid succession. The Smart-inhaler and Doser are both highly accurate at measuring actuated doses and no spurious doses were recorded in an in vitro setting. (c) 2005 Elsevier Ltd. All rights reserved.