Per- and polyfluoroalkyl substances and psychosocial stressors have a joint effect on adverse pregnancy outcomes in the Atlanta African American Maternal-Child cohort.
Per- and polyfluoroalkyl substances and psychosocial stressors have a joint effect on adverse pregnancy outcomes in the Atlanta African American Maternal-Child cohort.
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全氟烷基物质和多氟烷基物质以及社会心理压力源对亚特兰大非裔美国母婴队列中的不良妊娠结局具有共同影响。
DOI：
10.1016/j.scitotenv.2022.159450
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Dunlop,AnneL
中科院分区：
文献类型：
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作者：
Eick,StephanieM;Barr,DanaBoyd;Brennan,PatriciaA;Taibl,KaitlinR;Tan,Youran;Robinson,Morgan;Kannan,Kurunthachalam;Panuwet,Parinya;Yakimavets,Volha;Ryan,PBarry;Liang,Donghai;Dunlop,AnneL
背景非裔美国人（AAs）经历不良妊娠结局相对于白人的高利率。子宫内暴露于环境化学品和心理社会压力因素的差异可能解释了观察到的一些健康差异，因为暴露于全氟和多氟烷基物质（PFAS）和歧视的经历与不良的出生结果有关。很少有研究将化学品和非化学压力源作为一种接触混合物进行研究，这可能更好地反映现实生活中的接触模式。在这里，我们采用的方法设计的暴露混合物的分析，以检查PFAS和心理社会压力对AAS.Methods348亚特兰大非裔美国人的母亲，儿童队列的出生结果的联合影响。在孕早期血清样本中测定了四种PFAS。自我报告问卷在头三个月进行管理，并用于评估心理社会压力（感知压力，抑郁，焦虑，性别种族压力）。使用分位数g计算和贝叶斯核机器回归（BKMR）来估计PFAS和心理社会压力对分娩时胎龄和胎龄z评分的出生体重的联合影响。所有的模型进行了调整，产妇教育，产妇年龄，奇偶校验，和任何酒精，烟草和大麻use.ResultsOur分析样本包括一个社会经济上不同的孕妇群体，79%接受公共医疗保险。在分位数g计算模型中，所有PFAS、感知压力、抑郁、焦虑和性别种族压力同时增加四分之一与出生体重z评分降低相关（每四分位数增加的平均%变化= −0.24，95%置信区间= −0.43，−0.06）。BKMR同样表明，增加所有的接触混合物与出生体重Z分数的适度下降，但不是一个减少长度的gesture.DiscussionUsing设计用于分析暴露混合物的方法，我们发现，同时增加在子宫内PFAS和心理社会压力与出生体重降低胎龄Z分数。
BackgroundAfrican Americans (AAs) experience high rates of adverse pregnancy outcomes relative to Whites. Differential in utero exposure to environmental chemicals and psychosocial stressors may explain some of the observed health disparities, as exposures to per- and polyfluoroalkyl substances (PFAS) and experiences of discrimination have been linked to adverse birth outcomes. Few studies have examined chemicals and non-chemical stressors together as an exposure mixture, which may better reflect real-life exposure patterns. Here, we adapted methods designed for the analysis of exposure mixtures to examine joint effects of PFAS and psychosocial stress on birth outcomes among AAs.Methods348 participants from the Atlanta African American Maternal-Child cohort were included in this study. Four PFAS were measured in first trimester serum samples. Self-report questionnaires were administered during the first trimester and were used to assess psychosocial stress (perceived stress, depression, anxiety, gendered racial stress). Quantile g-computation and Bayesian kernel machine regression (BKMR) were used to estimate the joint effects between PFAS and psychosocial stressors on gestational age at delivery and birthweight for gestational age z-scores. All models were adjusted for maternal education, maternal age, parity, and any alcohol, tobacco and marijuana use.ResultsOur analytic sample included a socioeconomically diverse group of pregnant women, with 79 % receiving public health insurance. In quantile g-computation models, a simultaneous one-quartile increase in all PFAS, perceived stress, depression, anxiety, and gendered racial stress was associated with a reduction in birthweight z-scores (mean %change per quartile increase = −0.24, 95 % confidence interval = −0.43, −0.06). BKMR similarly showed that increasing all exposures in the mixture was associated with a modest decrease in birthweight z-scores, but not a reduced length of gestation.DiscussionUsing methods designed for analyzing exposure mixtures, we found that a simultaneous increase in in utero PFAS and psychosocial stressors was associated with reduced birthweight for gestational age z-scores.