Wnt signaling in polycystic kidney disease
Wnt signaling in polycystic kidney disease
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DOI：
10.1681/asn.2006121355
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发表时间：
2007-05-01
影响因子：
13.6
通讯作者：
Walz, Gerd
中科院分区：
文献类型：
--
作者：
Benzing, Thomas;Simons, Matias;Walz, Gerd
Wnt信号级联激活从细胞迁移和增殖到细胞命运决定和干细胞更新的形态发生程序。这些途径使细胞能够将环境线索转化为组织组织和构建器官所需的复杂细胞程序。Wnt信号传导对肾脏发育至关重要;然而，所涉及的特定分子基础知之甚少。最近的研究揭示了Wnt信号与多囊肾疾病之间的意想不到的交叉点。发现一些多囊肾疾病蛋白质，如Inversin和Bardet-Biedl综合征家族成员，使用Wnt信号级联的组分使细胞沿着上皮平面内的次级极性轴定向。可能需要这些空间线索来定位具有限定几何形状的新生小管。
Wnt signaling cascades activate morphogenetic programs that range from cell migration and proliferation to cell fate determination and stem cell renewal. These pathways enable cells to translate environmental cues into the complex cellular programs that are needed to organize tissues and build organs. Wnt signaling is essential for renal development; however, the specific molecular underpinnings involved are poorly understood. Recent research has revealed an unexpected intersection between Wnt signaling and polycystic kidney disease. Some polycystic kidney disease proteins, such as Inversin and Bardet-Biedl syndrome family members, were found to use components of the Wnt signaling cascade to orient cells along a secondary polarity axis within the plane of the epithelium. These spatial cues may be needed to position nascent tubules with a defined geometry.