Gene X environment interaction of vigorous exercise and body mass index among male Vietnam-era twins
Gene X environment interaction of vigorous exercise and body mass index among male Vietnam-era twins
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DOI：
10.3945/ajcn.2008.27170
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发表时间：
2009-04-01
影响因子：
7.1
通讯作者：
Wing, Rena R.
中科院分区：
文献类型：
--
作者：
McCaffery, Jeanne M.;Papandonatos, George D.;Wing, Rena R.
背景：过去几十年的长期趋势表明环境对体重指数（BMI）的影响。然而，双胞胎模型，包括基因-环境相关性和基因X环境相互作用还没有被应用到阐明特定的环境因素，影响遗传力的bim.Objective：我们的目的是确定是否一个假定的环境预测肥胖，剧烈运动，显示证据的基因-环境相关性或基因X环境相互作用与BMI的双胞胎。设计：双胞胎结构方程模型被用来研究基因-环境相关性和基因X环境相互作用的剧烈运动与BMI之间的2710单卵和2327双卵男性-男性双胞胎对从越南时代双胞胎登记处-一个国家登记的双胞胎对谁在军队中服役在越南战争时期。结果：剧烈运动显著改变了BMI的加性遗传成分，表明存在基因×环境互作（P < 0.001）。BMI在那些没有报告剧烈运动的人中显示出最大的遗传影响，而在那些报告剧烈运动的人中遗传影响减弱。此外，剧烈运动有一个小的，但显着的环境影响BMI（P = 0.006）-一个发现证实单卵双胞胎不一致的剧烈exercise.Conclusions：基因对BMI的影响是低的那些谁报告剧烈运动。与一个新兴的文献相一致，这表明剧烈运动可能会减轻一些遗传对肥胖的影响。肥胖的分子遗传学研究应考虑结合行为和人口因素的措施，以最大限度地确定新的肥胖基因。美国临床营养杂志2009;89：1011-8。
Background: Secular trends over the past several decades suggest an environmental influence on body mass index (BMI). However, twin models that incorporate a gene-environment correlation and gene X environment interaction have not been applied to elucidate specific environmental factors that affect the heritability of BMI.Objective: Our aim was to determine whether one putative environmental predictor of obesity, vigorous exercise, shows evidence of a gene-environment correlation or gene X environment interaction with BMI among twins.Design: Twin structural equation modeling was used to examine a gene-environment correlation and a gene X environment interaction of vigorous exercise with BMI among 2710 monozygotic and 2327 dizygotic male-male twin pairs from the Vietnam Era Twin Registry-a national registry of twin pairs who served in the military during the Vietnam War era.Results: Vigorous exercise significantly modified the additive genetic component of BMI, which indicated a gene X environment interaction (P < 0.001). BMI showed the greatest genetic influence among those who did not report vigorous exercise, with diminished genetic influence among those who did. Furthermore, vigorous exercise had a small but significant environmental effect on BMI (P = 0.006)-a finding confirmed among monozygotic co-twins discordant for vigorous exercise.Conclusions: Genetic influences on BMI are lower among those who report vigorous exercise. Consistent with an emerging literature, this suggests that vigorous exercise may mitigate some of the genetic influence on obesity. Molecular genetic studies of obesity should consider incorporating measures of behavioral and demographic factors to maximize the identification of novel obesity genes. Am J Clin Nutr 2009;89:1011-8.