The effect of antigen dose on T cell-targeting vaccine outcome
The effect of antigen dose on T cell-targeting vaccine outcome
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DOI：
10.1080/21645515.2018.1527496
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发表时间：
2019-02-01
影响因子：
4.8
通讯作者：
Berzofsky, Jay A.
中科院分区：
文献类型：
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作者：
Billeskov, Rolf;Beikzadeh, Babak;Berzofsky, Jay A.
在过去的3-4年里，越来越多的证据表明，抗原剂量或T细胞受体（TCR）刺激强度对随后的反应类型、持续时间和“风味”或质量具有复杂的作用。抗原剂量最初被证明影响Th1/Th2偏倚，后来也被证明对Tregs、Th17、t -滤泡辅助（Tfh）、细胞和其他细胞的发育和诱导有不同的影响。近年来，在感染、癌症和/或自身免疫过程中，CD4/8 T细胞的质量已被证明对随后的疾病结果至关重要。重要的是，不同的疫苗接种策略也会导致不同类型的T细胞反应，抗原剂量的作用正在成为研究人员微调疫苗功效的重要因素和工具。本评论将强调抗原剂量如何影响和影响T细胞反应质量的基本背景，并讨论这在不同的疫苗设置中如何转化。
During the past 3-4 decades, an increasing amount of evidence has pointed to the complex role of the antigen dose or T cell receptor (TCR) stimulation strength on the subsequent type, duration and "flavor" or quality of the response. Antigen dose was initially shown to impact Th1/Th2 bias, and later also shown to differentially affect development and induction of Tregs, Th17, T-follicular helper (Tfh), cells, and others. In recent years the quality of both CD4/8 T cells during infections, cancer and/or autoimmunity has turned out to be critical for subsequent disease outcome. Importantly, different vaccination strategies also lead to different types of T cell responses, and the role of the antigen dose is emerging as an important factor as well as a tool for investigators to utilize in fine-tuning vaccine efficacy. This commentary will highlight essential background of how antigen dose can impact and affect the quality of T cell responses, and discuss how this translates in different vaccine settings.