Endocannabinoid signaling system and brain reward: Emphasis on dopamine
Endocannabinoid signaling system and brain reward: Emphasis on dopamine
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DOI：
10.1016/j.pbb.2005.01.032
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发表时间：
2005-06-01
影响因子：
3.6
通讯作者：
Gardner, EL
中科院分区：
文献类型：
--
作者：
Gardner, EL
大脑的奖赏回路由腹侧被盖区（VTA）、延髓核（Acb）和连接VTA和Acb的内侧前脑束（MFB）部分中的多巴胺能（DA）神经元的“串联”回路组成。增强大脑奖励（并具有衍生成瘾潜力）的药物对这个核心DA奖励系统和与其功能相关的动物行为具有共同作用。这类药物增强了奖励系统中的脑电刺激奖励;增强了其中的神经放电和DA音调;产生了条件性位置偏好（CPP），这是一种激励动机的行为模型;是自我管理的;并触发了从药物自我管理中消失的动物的药物寻求行为的恢复。大麻素长期以来被认为与其他奖励增强药物在奖励功效和激活的潜在神经生物学底物方面不同。然而，现在很清楚，大麻素激活这些大脑奖励过程和奖励相关行为的方式与其他奖励增强药物类似。这篇简短的综述讨论了内源性大麻素（特别是CB 1受体的激活）可能在核心奖励系统中发挥的作用，并得出结论，虽然大麻素以与其他奖励增强药物一致的方式激活奖励途径，但发生这种情况的神经机制可能不同。爱思唯尔公司出版
The brain's reward circuitry consists of an "in series" circuit of dopaminergic (DA) neurons in the ventral tegmental area (VTA), nucleus accumbens (Acb), and that portion of the medial forebrain bundle (MFB) which links the VTA and Acb. Drugs which enhance brain reward (and have derivative addictive potential) have common actions on this core DA reward system and on animal behaviors relating to its function. Such drugs enhance electrical brain-stimulation reward in this reward system; enhance neural firing and DA tone within it; produce conditioned place preference (CPP), a behavioral model of incentive motivation; are self-administered; and trigger reinstatement of drug-seeking behavior in animals extinguished from drug self-administration. Cannabinoids were long considered different from other reward-enhancing drugs in reward efficacy and in underlying neurobiological substrates activated. However, it is now clear that cannabinoids activate these brain reward processes and reward-related behaviors in similar fashion to other reward-enhancing drugs. This brief review discusses the roles that endogenous cannabinoids (especially activation of the CB1 receptor) may play within the core reward system, and concludes that while cannabinoids activate the reward pathways in a manner consistent with other reward-enhancing drugs, the neural mechanisms by which this occurs may differ. Published by Elsevier Inc.