Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation
Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation
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莫达非尼通过抑制睡眠剥夺小鼠的过度自噬和细胞凋亡来保护海马神经元
DOI：
10.1111/bph.14626
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发表时间：
2019-05-01
影响因子：
7.3
通讯作者：
Wu, Xiaojun
中科院分区：
文献类型：
--
作者：
Cao, Yin;Li, Qinglin;Wu, Xiaojun
睡眠剥夺会损害人类和动物的学习和记忆能力，这可以通过服用莫达非尼（一种促进清醒的药物）来逆转。功能失调的自噬增加了凋亡级联的激活，最终导致神经元死亡增加，可通过自噬抑制剂缓解。本研究旨在探讨莫达非尼对睡眠剥夺所致学习记忆缺失小鼠海马过度自噬的缓解作用及其机制。
Sleep deprivation compromises learning and memory in both humans and animals, and can be reversed by administration of modafinil, a drug promoting wakefulness. Dysfunctional autophagy increases activation of apoptotic cascades, ultimately leading to increased neuronal death, which can be alleviated by autophagy inhibitors. This study aimed to investigate the alleviative effect and mechanism of modafinil on the excessive autophagy occurring in the hippocampus of mice with deficiency of learning and memory induced by sleep deprivation.