Regulation of CD38 expression and function by steroid hormones in myometrium
Regulation of CD38 expression and function by steroid hormones in myometrium
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DOI：
10.1016/j.mce.2005.11.014
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发表时间：
2006-02-26
影响因子：
4.1
通讯作者：
Kannan, MS
中科院分区：
文献类型：
--
作者：
Dogan, S;Deshpande, DA;Kannan, MS
CD38 是一种 45 kDa 跨膜糖蛋白，在许多细胞类型中普遍表达，包括子宫肌层平滑肌细胞。 CD38是一种双功能蛋白，同时具有ADP-核糖基环化酶(cyclase)和环状ADP-核糖(cADPR)-水解酶(Hydrolase)活性。环化酶将 β-NAD 转化为 cADPR，这是一种参与受精、胰岛素分泌和肌肉收缩的钙动员第二信使。平滑肌中的 CD38 表达受细胞因子、类固醇激素雌激素和黄体酮以及大鼠妊娠期间的调节。雌激素增加 CD38 表达，这与环化酶活性增加有关，但与水解酶活性无关，表明翻译后调节存在差异。黄体酮减弱雌激素诱导的对 CD38 表达和活性的影响。这将对分娩过程中钙动员和子宫肌层收缩力的增加产生影响。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
CD38, a 45-kDa transmembrane glycoprotein, is expressed ubiquitously in many cell types, including the myometrial smooth muscle cells. CD38 is a bifunctional protein, and has both ADP-ribosyl cyclase (cyclase) and cyclic ADP-ribose (cADPR)-hydrolase (hydrolase) activities. The cyclase converts beta-NAD to cADPR, a calcium mobilizing second messenger involved in fertilization, insulin secretion, and muscle contraction. CD38 expression in smooth muscle is regulated by cytokines, by the steroid hormones estrogen and progesterone, and during gestation in the rat. Estrogen increases CD38 expression, which is associated with increased cyclase, but not hydrolase, activity, indicating a differential post-translational regulation. Progesterone attenuates estrogen-induced effects on CD38 expression and activities. This will have implications for increased calcium mobilization and contractility of the myometrium during parturition. (c) 2005 Elsevier Ireland Ltd. All rights reserved.